Table 1 Revised 2010 Task Force Criteria for ARVC*

1. Global or regional dysfunction and structural alterations

Major

2D Echo Criteria

Regional RV akinesia, dyskinesia, or aneurysm AND 1 of the following measured at end diastole:

CMR criteria

Regional RV akinesia or dyskinesia or dyssynchronous RV contraction AND 1 of the following:

RV angiography criteria

Regional RV akinesia, dyskinesia, or aneurysm

Minor

2D Echo Criteria

Regional RV akinesia or dyskinesia or dyssynchronous RV contraction AND 1 of the following measured at end diastole:

CMR criteria

Regional RV akinesia or dyskinesia or dyssynchronous RV contraction AND 1 of the following:

2.Tissue characterization of wall

Major

Residual myocytes < 60% by morphometric analysis (or < 50% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample, with or without fatty replacement of tissue on endomyocardial biopsy

Minor

Residual myocytes 60% to 75% by morphometric analysis (or 50% to 65% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample with or without fatty replacement of tissue on endomyocardial biopsy

3. Repolarization abnormalities

Major

Inverted T waves in right precordial leads (V1, V2, and V3) or beyond in individuals >14 yrs of age (in the absence of complete RBBB QRS ≥ 120 ms)

Minor

Inverted T waves in V1 and V2 in individuals >14 yrs of age (in the absence of complete RBBB) or in V4, V5, and V6

Inverted T waves in leads V1, V2, V3, and V4 in individuals >14 years of age in the presence of a complete RBBB

4. Depolarization/conduction abnormalities

Major

Epsilon wave (reproducible low-amplitude signals between end of QRS complex to onset of T wave) in the right precordial leads (V1 - V3)

Minor

Late potentials by SAECG in ≥1 of 3 parameters in the absence of a QRSd of ≥110 msec on standard ECG:

- Filtered QRS duration (fQRS) ≥ 114 msec

- Duration of terminal QRS < 40 microV ≥ 38 ms

- Root-mean-square voltage of terminal 40 ms ≤20 micro V

Terminal activation duration ≥ 55 ms measured from the nadir of the S-wave until the end of all depolarization deflections (including R') in V1, V2, or V3

5. Arrhythmias

Major

Nonsustained or sustained VT of LBBB morphology with superior axis

Minor

Nonsustained or sustained VT of RVOT configuration, LBBB morphology with inferior axis or of unknown axis

> 500 PVCs per 24 hours on Holter monitoring

6. Family History

Major

ARVC in first degree relative who meets Task Force Criteria

ARVC confirmed pathologically at autopsy or surgery in first degree relative

Identification of pathogenic mutation categorized as associated or probably associated with ARVC in the patient under evaluation

Minor

History of ARVC in first degree relative in whom it is not possible to determine whether the family member meets Task Force Criteria

Premature sudden death (<35 years of age) due to suspected ARVC in a first degree relative

ARVC confirmed pathologically or by current Task Force Criteria in second-degree relative