Multiparametric cardiovascular magnetic resonance surveillance of acute cardiac allograft rejection and characterisation of transplantation-associated myocardial injury: a pilot study

Table 1 Baseline subject characteristics

	Transplant patients (n = 22)	Healthy volunteers (n = 10)	p value
Male	17 (77%)	7 (70%)	0.660
Age (years)	49 ± 10	49 ± 8	0.961
Non-white	2 (9%)	1 (10%)	0.676
BSA (m²)	1.86 ± 0.20	1.94 ± 0.19	0.290
BMI (kg/m²)	24.7 ± 3.6	25.7 ± 4.1	0.484
eGFR (mL/min/m²)	61 ± 24	89 ± 13	<0.001
HR (bpm)	89 ± 15	60 ± 6	<0.001
Systolic BP (mmHg)	135 ± 17	111 ± 8	<0.001
Indication for transplant
DCM	12 (55%)	-
IHD	6 (27%)	-
ARVC	2 (9%)	-
HCM	1 (5%)	-
Re-transplant	1 (5%)	-
Pregnancy prior to transplantation	3 (14%)	-
VAD prior to transplantation	1 (5%)	-
Donor age (years)	42 ± 7	-
Donor male	17 (77%)	-
Donor: recipient gender match	18 (82%)	-
Donor cause of death
ICH	13 (59%)	-
Head trauma	5 (23%)	-
Other	4 (18%)	-
CMV donor pos., recipient neg.	5 (23%)	-
Ischaemic time (min)	184 ± 52	-
Induction immunosuppression
rATG	21 (95%)	-
Basiliximab	1 (5%)	-
Initial immunosuppression regime
Cyclosporine/prednisolone/MMF	21 (95%)	-
Tacrolimus/prednisolone/MMF	1 (5%)	-
ICU stay (days)	17 ± 19	-
Hospital stay (days)	36 ± 23	-

BSA indicates body surface area; BMI body mass index; eGFR estimated glomerular filtration rate; HR heart rate; BP blood pressure; DCM indicates dilated cardiomyopathy; IHD ischemic heart disease; ARVC arrhythmogenic right ventricular cardiomyopathy; HCM hypertrophic cardiomyopathy; (Re-transplant: this patient suffered immediate graft failure and therefore underwent a second transplantation); VAD ventricular assist device; ICH spontaneous intracranial haemorrhage; CMV cytomegalovirus; rATG rabbit antithymocyte globulin; MMF Mycophenolate mofetil; ICU intensive care unit.

ISSN: 1532-429X