| |
Scan 1 (6.9 weeks)
|
Scan 2 (10.9 weeks)
|
Scan 3 (16.6 weeks)
|
Scan 4 (22.3 weeks)
|
p value
|
Healthy volunteers
|
|---|
|
LVEDVI (mL/m2)
|
83.2 ± 20.3
|
83.4 ± 23.2
|
83.7 ± 22.6
|
82.6 ± 19.9
|
0.979
|
85.9 ± 8.1
|
|
LVESVI (mL/m2)
|
35.3 ± 21.1
|
35.8 ± 23.6
|
34.5 ± 21.2
|
33.5 ± 19.4
|
0.423
|
28.5 ± 4.3
|
|
LVEF (%)
|
59.5 ± 13.2
|
60.1 ± 14.2
|
61.1 ± 13.9
|
61.3 ± 12.2
|
0.216
|
66.9 ± 4.2
|
|
LVMI (g/m2)
|
63.6 ± 15.7
|
62.5 ± 12.9
|
62.1 ± 12.8
|
59.3 ± 11.9
|
0.001
|
46.4 ± 7.3†
|
|
εcc (%)
|
−12.4 ± 3.8
|
−13.5 ± 2.9
|
−14.2 ± 3.8
|
−14.4 ± 3.0
|
0.024
|
−20.7 ± 1.0†
|
|
Peak systolic SR (1/s)
|
−1.05 ± 0.33
|
−1.03 ± 0.27
|
−1.07 ± 0.33
|
−1.05 ± 0.30
|
0.669
|
−1.17 ± 0.14
|
|
Early diastolic SR (1/s)
|
0.29 ± 0.13
|
0.25 ± 0.10
|
0.23 ± 0.12
|
0.25 ± 0.15
|
0.499
|
0.37 ± 0.20
|
|
Normalised twist (°/mm)
|
0.26 ± 0.10
|
0.25 ± 0.10
|
0.27 ± 0.11
|
0.27 ± 0.08
|
0.709
|
0.34 ± 0.12*
|
|
Torsion (mm)
|
7.68 ± 2.89
|
7.16 ± 2.73
|
7.78 ± 3.19
|
7.59 ± 2.24
|
0.761
|
8.99 ± 3.11
|
|
Time to peak torsion (% AVC)
|
101.0 ± 11.0
|
97.1 ± 7.2
|
97.9 ± 6.3
|
96.5 ± 9.3
|
0.466
|
96.4 ± 5.5
|
|
Native T1 (ms)
|
1109 ± 53
|
1089 ± 62
|
1084 ± 70
|
1063 ± 40
|
<0.001
|
989 ± 46†
|
|
T2 (ms)
|
58.7 ± 3.4
|
57.1 ± 3.4
|
56.9 ± 2.9
|
55.9 ± 2.9
|
0.003
|
54.1 ± 2.0
|
|
Resting MBF (mL/min/g)
|
-
|
0.85 ± 0.12
|
-
|
0.86 ± 0.16
|
0.150
|
0.74 ± 0.10
|
|
Stress MBF (mL/min/g)
|
-
|
1.21 ± 0.18
|
-
|
1.37 ± 0.26
|
0.172
|
1.81 ± 0.29†
|
|
MPR
|
-
|
1.44 ± 0.22
|
-
|
1.62 ± 0.35
|
0.023
|
2.46 ± 0.34†
|
|
ECV
|
-
|
30.1 ± 0.5
|
-
|
28.0 ± 1.6
|
<0.001
|
25.3 ± 0.18†
|
- Time between transplantation and scan is given in brackets.
- p values refer to the significance of the difference between scans. The significance of the difference between healthy volunteers and scan 4 is denoted by *(p < 0.05) and †(p < 0.01). MBF indicates myocardial blood flow; MPR myocardial perfusion reserve; LGE late gadolinium enhancement; ECV myocardial extracellular volume. Other abbreviations as per Table 2.
