| Scan 1 (6.9 weeks) | Scan 2 (10.9 weeks) | Scan 3 (16.6 weeks) | Scan 4 (22.3 weeks) | p value | Healthy volunteers |
---|---|---|---|---|---|---|
LVEDVI (mL/m2) | 83.2 ± 20.3 | 83.4 ± 23.2 | 83.7 ± 22.6 | 82.6 ± 19.9 | 0.979 | 85.9 ± 8.1 |
LVESVI (mL/m2) | 35.3 ± 21.1 | 35.8 ± 23.6 | 34.5 ± 21.2 | 33.5 ± 19.4 | 0.423 | 28.5 ± 4.3 |
LVEF (%) | 59.5 ± 13.2 | 60.1 ± 14.2 | 61.1 ± 13.9 | 61.3 ± 12.2 | 0.216 | 66.9 ± 4.2 |
LVMI (g/m2) | 63.6 ± 15.7 | 62.5 ± 12.9 | 62.1 ± 12.8 | 59.3 ± 11.9 | 0.001 | 46.4 ± 7.3†|
εcc (%) | −12.4 ± 3.8 | −13.5 ± 2.9 | −14.2 ± 3.8 | −14.4 ± 3.0 | 0.024 | −20.7 ± 1.0†|
Peak systolic SR (1/s) | −1.05 ± 0.33 | −1.03 ± 0.27 | −1.07 ± 0.33 | −1.05 ± 0.30 | 0.669 | −1.17 ± 0.14 |
Early diastolic SR (1/s) | 0.29 ± 0.13 | 0.25 ± 0.10 | 0.23 ± 0.12 | 0.25 ± 0.15 | 0.499 | 0.37 ± 0.20 |
Normalised twist (°/mm) | 0.26 ± 0.10 | 0.25 ± 0.10 | 0.27 ± 0.11 | 0.27 ± 0.08 | 0.709 | 0.34 ± 0.12* |
Torsion (mm) | 7.68 ± 2.89 | 7.16 ± 2.73 | 7.78 ± 3.19 | 7.59 ± 2.24 | 0.761 | 8.99 ± 3.11 |
Time to peak torsion (% AVC) | 101.0 ± 11.0 | 97.1 ± 7.2 | 97.9 ± 6.3 | 96.5 ± 9.3 | 0.466 | 96.4 ± 5.5 |
Native T1 (ms) | 1109 ± 53 | 1089 ± 62 | 1084 ± 70 | 1063 ± 40 | <0.001 | 989 ± 46†|
T2 (ms) | 58.7 ± 3.4 | 57.1 ± 3.4 | 56.9 ± 2.9 | 55.9 ± 2.9 | 0.003 | 54.1 ± 2.0 |
Resting MBF (mL/min/g) | - | 0.85 ± 0.12 | - | 0.86 ± 0.16 | 0.150 | 0.74 ± 0.10 |
Stress MBF (mL/min/g) | - | 1.21 ± 0.18 | - | 1.37 ± 0.26 | 0.172 | 1.81 ± 0.29†|
MPR | - | 1.44 ± 0.22 | - | 1.62 ± 0.35 | 0.023 | 2.46 ± 0.34†|
ECV | - | 30.1 ± 0.5 | - | 28.0 ± 1.6 | <0.001 | 25.3 ± 0.18†|