Skip to main content

Table 1 Patient details, cardiac iron concentration and summary of CMR measurements

From: Calibration of myocardial T2 and T1 against iron concentration

Patient

Sex

Diagnosis

Death or cardiac transplantation

Age at death or transplantation

Cause of death or indication for transplant

LV [Fe] [mg/g dw] (mean ± SD)

Global myocardial T1 [ms] (mean ± SD)

Variability of T1 (CoV%)

Global myocardial T2 [ms] (mean ± SD)

Variability of T2 (CoV%)

Total estimated units transfused

Global myocardial T2* [ms] (mean ± SD)

1

M

TM

Death

46

Ischemic stroke (no cardiac failure)

0.38 ± 0.13

351.4 ± 37.2

10.6

72.7 ± 7.5

10.3

1584

44.4 ± 5.3

2

F

SA

Death

62

Cardiac failure

8.20 ± 1.44

246.1 ± 37.7

16.0

18.6 ± 2.0

12.3

2000

4.7 ± 0.6

3

M

TM

Death*

10

Cardiac failure

9.50 ± 1.88

93.0 ± 28.4

30.5

14.5 ± 1.3

8.9

170

3.7 ± 0.6

4

F

TM

Death†

15

Cardiac failure

25.9 ± 10.3

-

-

-

-

288

2.0 ± 0.4

5

F

TM

Death

20

Cardiac failure

7.74 ± 1.51

80.1 ± 26.0

32.5

18.2 ± 2.4

12.9

432

3.6 ± 0.5

6

M

TM

Transplant

23

Cardiac failure

3.63 ± 0.82

52.3 ± 13.6

26.1

20.3 ± 1.8

9.0

765

8.0 ± 1.0

7

M

TM

Transplant

24

Cardiac failure

3.38 ± 0.53

68.9 ± 21.8

31.5

21.9 ± 2.7

12.2

528

7.7 ± 1.2

8

M

TM

Transplant

21

Cardiac failure

5.87 ± 1.0

70.4 ± 20.1

28.6

17.6 ± 2.1

11.7

500

4.4 ± 0.6

9

F

TM

Transplant

31

Cardiac failure

8.78 ± 1.88

68.0 ± 27.1

39.8

13.5 ± 1.9

14.3

624

3.9 ± 0.6

10

M

TM

Death

24

Cardiac failure & mucormycosis

5.64 ± 1.36

247.2 ± 23.7

9.6

24.7 ± 2.5

10.0

660

5.8 ± 1.4

11

M

TM

Death

44

Cardiac failure

3.19 ± 1.02

305.3 ± 28.0

9.0

43.3 ± 5.0

11.4

1209

12.3 ± 2.6

12

M

DBA

Death

22

Cardiac failure & pneumonia

3.91 ± 0.86

206.4 ± 26.9

9.5

26.8 ± 3.5

12.7

442

8.8 ± 1.8

  1. T2 values are time-corrected as described in the text. SD = standard deviation, LV = left ventricle, [Fe] = myocardial iron concentration, TM = Beta thalassaemia major, SA = Sideroblastic anaemia, DBA = Diamond Blackfan anaemia, N/A = not applicable (patients 3 and 4 did not receive iron chelation therapy: *died 1964; †died 1972). Note hearts 3 – 9 were all stored in formalin for over a year prior to scanning. For comparison, global T2* values are shown in the right-hand column.