A case study of a symptomatic subject with an atherosclerotic plaque of 80% stenosis in the right internal carotid artery. Pre-contrast T2-weighted image and T1-weighted image were both iso-intense in the plaque area. Post-contrast T1-weighted TSE image showed a hypo-intense area within the plaque surrounded by enhanced tissue, indicating a large LRNC. DWI (b = 300 mm2/s) using DP-TSE shows a hyper-intense region, i.e. low diffusion, that spatially matched to the LRNC area in the post-contrast T1-weighted image. ADC map showed an area with low diffusion (0.46 ± 0.22 × 10−3 mm2/s) within the plaque that also spatially matched to the LRNC finding in the post-contrast T1-weighted image.