Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study

Table 1 Subject characteristics

Variables	Healthy volunteers	Low risk patients	Sig.
Variables	(n = 102)	(n = 113)	(p-value)
Age (years)	41 ± 17	44 ± 14	0.21
Gender (male(n,%))	53 (52)	57 (51)	0.88
BMI	26 ± 4	26 ± 4	0.97
Heart rate (bpm)	66 ± 11	67 ± 13	0.26
Systolic BP (mmHg)	119 ± 11	121 ± 15	0.27
Diastolic BP (mmHg)	71 ± 11	75 ± 9	0.39
eGFR (ml/m²)	92 ± 36	97 ± 25	0.57
Hematocrit (%)	40 ± 0.04	41 ± 0.04	0.91
LV-EDV index (ml/m²)	79 ± 15	77 ± 13	0.41
LV-ESV index (ml/m²)	30 ± 8	30 ± 7	0.79
LV-EF (%)	63 ± 5	62 ± 5	0.37
RV-EF (%)	59 ± 7	58 ± 7	0.89
LV mass index (g/m²)	51 ± 12	53 ± 13	0.21
LA area (g/m²)	22 ± 4	21 ± 4	0.49
1.5 T	(n = 34)	(n = 58)
Native T1_myocardium (msec)	950 ± 21	952 ± 23	0.66
Native T1_blood (msec)	1551 ± 115	1572 ± 111	0.36
Postcontrast T1 _myocardium (msec)	415 ± 113	406 ± 94	0.77
Postcontrast T1 _blood (msec)	291 ± 122	278 ± 107	0.51
λ	0.44 ± 0.06	0.43 ± 0.08	0.72
ECV	0.25 ± 0.04	0.26 ± 0.06	0.32
3 T	(n = 32)	(n = 55)
Native T1_myocardium (msec)	1052 ± 23	1053 ± 24	0.51
Native T1_blood (msec)	1736 ± 139	1716 ± 149	0.64
Postcontrast T1 _myocardium (msec)	421 ± 131	402 ± 117	0.81
Postcontrast T1 _blood (msec)	277 ± 106	250 ± 112	0.69
λ	0.44 ± 0.07	0.43 ± 0.09	0.46
ECV	0.26 ± 0.04	0.26 ± 0.06	0.72

BMI – Body mass index, BP – blood pressure. Student t-test, P < 0.05 is considered significant. A total of 179 subjects underwent a contrast-enhanced study (healthy volunteers, n = 66; patients, n = 113). Student t-test or one-way ANOVA, P < 0.05 is considered significant.

ISSN: 1532-429X