Adjusted and unadjusted measures of myocardial oxygen demand. A shows the unadjusted differences in myocardial oxygen demand with stress, specifically the PVA, between Groups II and II. The differences in the unadjusted PVA between Groups II and III are attenuated when adjusted for LV preload (LV End-diastolic volume (LVEDV)) and LV concentricity, but persist when adjusted for LV afterload (Aortic pulse wave velocity (PWV) and LV contractility (LV ejection fraction (LVEF). B demonstrates the differences in Stroke work between Groups II and III. Similar to PVA, LV Preload and Concentricity determine the differences in the Stroke Work between Groups II and III, but not the LV afterload or contractility. A and B show the attenuation of these differences when adjusted for LV preload and concentricity respectively. This suggests that LV preload and concentricity are the main factors influencing myocardial oxygen demand.