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Fig. 1 | Journal of Cardiovascular Magnetic Resonance

Fig. 1

From: Focal myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in children and adolescents with dilated cardiomyopathy

Fig. 1

Example of two patients with DCM and no signs of myocardial fibrosis assessed by LGE CMR and the corresponding histopathological and immunohistochemical findings CMR images of a 6 month-old patient with idiopathic DCM (A-C) and of a 4 month-old patient with DCM with lymphocytic myocarditis (G-I). Masson’s trichrome staining (D and J) reveals in both patients lesions characterized by interstitial fibrosis (blue) and the presence of degenerated myocytes. While in the patient with inflammatory cardiomyopathy the number of T lymphocytes (CD3) (K) and expression of HLA II class molecules on macrophages were increased (L), the uninflamed heart revealed no T cells (E) or enhanced expression of HLA class II molecules (F)

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