| Patients | Controls | p | ||||
---|---|---|---|---|---|---|---|
 | Rest | 10 μg/Kg/min | 20 μg/Kg/min | Rest | 10 μg/Kg/min | 20 μg/Kg/min |  |
Heart Rate (beats/min) | 72 (58-78) | 75 (63-84) | 94 (75-111) | 69 (51-72) | 65 (53-91) | 90 (72-118) | Â |
Δ Heart Rate (beats/min) |  | 3 (−2-10) |  |  | 3 (−5-14) |  | 0.94 |
 |  |  | 24 (5-34) |  |  | 25 (18-42) | 0.44 |
Stroke volume (ml) | 92 (80-110) | Â | 95 (73-113) | 93 (71-115) | Â | 117 (86-144) | Â |
Δ Stroke volume (ml) |  |  | −1.0 (−15-18) |  |  | 18 (4-29) | 0.037 |
Cardiac Output (l/min) | 6.5 (5.1-7.9) | Â | 9.2 (7.0-10.4) | 6.1 (5.1-6.6) | Â | 9.4 (8.6-11.5) | Â |
Δ Cardiac Output (l/min) |  |  | 2.2 (1.7-3.2) |  |  | 3.8 (3.4-4.9) | 0.015 |
Ejection Fraction (%)a | 66 (60-69) | 71 (65-74) | 73 (70-76) | 63 (61-67) | 73 (72-76) | 75 (73-79) | Â |
Δ Ejection Fraction (%) |  | 4 (2-8) |  |  | 10 (6-14) |  | 0.006 |
 |  |  | 8 (5-11) |  |  | 11 (7-17) | 0.08 |
GLS (%) | −18.9 (−16.0 to −20.5) | −19.7 (−15.9 to −22.4) | −19.5 (−16.6 to –21.6) | −19.0 (−16.1 to −20.6) | −23.4 (−22.1 to –26.7) | −21.8 (−19.9 to –23.6) |  |
Δ GLS (%) |  | −1.4 (1.0 to −3.1) |  |  | −5.9 (−3.6 to −8.2) |  | <0.001 |
 |  |  | −0.6 (1.0 to –3.0) |  |  | −2.5 (−2.3 to −5.1) | 0.018 |
GCS (%) | −27.5 (−24.1 to −30.6) | −31.2 (−25.6 to −35.7) | −35.7 (−30.3 to −39.3) | --27.7 (−24.9 to −30.1) | −34.7 (−32.2 to −36.3) | −36.1 (−34.8 to −37.3) |  |
Δ GCS (%) |  | −4.0 (−0.1 to −5.8) |  |  | −8.3 (−2.6 to −10.5) |  | 0.04 |
 |  |  | −7.6 (−3.7 to −11.0) |  |  | −9.1 (−5.0 to −13.2) | 0.48 |
GRS (%) | 33.9 (25.4-39.1) | 35.6 (28.9-41.8) | 38.1 (29.7-43.1) | 31.8 (28.5-40.0) | 39.1 (34.8-41.8) | 36.3 (33.9-41.4) | Â |
Δ GRS (%) |  | 1.9 (−0.9-5.3) |  |  | 4.2 (2.2-8.2) |  | 0.10 |
 |  |  | 4.2 (0.6-8.1) |  |  | 3.1 (−0.2-9.3) | 0.79 |