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Table 3 Hemodynamic and strain response to dobutamine

From: Assessment of cardiovascular physiology using dobutamine stress cardiovascular magnetic resonance reveals impaired contractile reserve in patients with cirrhotic cardiomyopathy

 

Patients

Controls

p

 

Rest

10 μg/Kg/min

20 μg/Kg/min

Rest

10 μg/Kg/min

20 μg/Kg/min

 

Heart Rate (beats/min)

72 (58-78)

75 (63-84)

94 (75-111)

69 (51-72)

65 (53-91)

90 (72-118)

 

Δ Heart Rate (beats/min)

 

3 (−2-10)

  

3 (−5-14)

 

0.94

   

24 (5-34)

  

25 (18-42)

0.44

Stroke volume (ml)

92 (80-110)

 

95 (73-113)

93 (71-115)

 

117 (86-144)

 

Δ Stroke volume (ml)

  

−1.0 (−15-18)

  

18 (4-29)

0.037

Cardiac Output (l/min)

6.5 (5.1-7.9)

 

9.2 (7.0-10.4)

6.1 (5.1-6.6)

 

9.4 (8.6-11.5)

 

Δ Cardiac Output (l/min)

  

2.2 (1.7-3.2)

  

3.8 (3.4-4.9)

0.015

Ejection Fraction (%)a

66 (60-69)

71 (65-74)

73 (70-76)

63 (61-67)

73 (72-76)

75 (73-79)

 

Δ Ejection Fraction (%)

 

4 (2-8)

  

10 (6-14)

 

0.006

   

8 (5-11)

  

11 (7-17)

0.08

GLS (%)

−18.9 (−16.0 to −20.5)

−19.7 (−15.9 to −22.4)

−19.5 (−16.6 to –21.6)

−19.0 (−16.1 to −20.6)

−23.4 (−22.1 to –26.7)

−21.8 (−19.9 to –23.6)

 

Δ GLS (%)

 

−1.4 (1.0 to −3.1)

  

−5.9 (−3.6 to −8.2)

 

<0.001

   

−0.6 (1.0 to –3.0)

  

−2.5 (−2.3 to −5.1)

0.018

GCS (%)

−27.5 (−24.1 to −30.6)

−31.2 (−25.6 to −35.7)

−35.7 (−30.3 to −39.3)

--27.7 (−24.9 to −30.1)

−34.7 (−32.2 to −36.3)

−36.1 (−34.8 to −37.3)

 

Δ GCS (%)

 

−4.0 (−0.1 to −5.8)

  

−8.3 (−2.6 to −10.5)

 

0.04

   

−7.6 (−3.7 to −11.0)

  

−9.1 (−5.0 to −13.2)

0.48

GRS (%)

33.9 (25.4-39.1)

35.6 (28.9-41.8)

38.1 (29.7-43.1)

31.8 (28.5-40.0)

39.1 (34.8-41.8)

36.3 (33.9-41.4)

 

Δ GRS (%)

 

1.9 (−0.9-5.3)

  

4.2 (2.2-8.2)

 

0.10

   

4.2 (0.6-8.1)

  

3.1 (−0.2-9.3)

0.79

  1. Results are presented as median (25th–75th percentile)
  2. GLS global longitudinal strain, GCG global circumferential strain, GRS global radial strain, Δ absolute variation from baseline
  3. aDerived from two long axis and one short axis