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Table 1 Patient characteristics

From: Prediction of response to cardiac resynchronization therapy using left ventricular pacing lead position and cardiovascular magnetic resonance derived wall motion patterns: a prospective cohort study

  All Patients Responders Non-responders P value
N = 33 N = 18 (55 %) N = 15 (45 %)
Age (years) 61 ± 13 61 ± 13 62 ± 12 0.72
Male, n (%) 18 (55) 7 (39) 11 (73) 0.08
NICM, n (%) 26 (79) 17 (94) 9 (60) 0.03
NHYA functional class 2.8 ± 0.4 2.8 ± 0.4 2.8 ± 0.4 0.86
Comorbidities, n (%)
Coronary artery disease 10 (30) 2 (11) 8 (53) 0.02
Diabetes mellitus 9 (27) 5 (28) 4 (27) 0.94
Hypertension 16 (49) 8 (44) 8 (53) 0.73
Dyslipidemia 17 (52) 8 (44) 9 (60) 0.49
Chronic kidney disease 7 (21) 3 (17) 4 (27) 0.67
Atrial fibrillation 7 (21) 4 (22) 3 (20) 0.88
Medications, n (%)
ACE inhibitor/ARB 32 (97) 18 (100) 14 (93) 0.46
Beta-blocker 32 (97) 18(100) 14 (93) 0.46
Aldosterone antagonist 11 (33) 6 (33) 5 (33) 1.00
Diuretic 23 (70) 13 (72) 10 (67) 0.73
Statin 18 (55) 8 (44) 10 (67) 0.30
Clinical variables
Body mass index (kg/m2) 28 ± 5 29 ± 4 28 ± 6 0.89
Resting heart rate (bpm) 73 ± 14 75 ± 17 71 ± 10 0.42
Serum creatinine (mg/dl) 1.06 ± 0.24 1.06 ± 0.24 1.07 ± 0.26 0.90
Favorable ECG patterna, n (%) 13 (39) 9 (50) 4 (27) 0.28
Echocardiographic variables
End-systolic volume (ml) 150 ± 71 143 ± 61 159 ± 84 0.55
Ejection fraction (%) 28 ± 9 27 ± 8 30 ± 9 0.37
Mitral regurgitation grade 1.1 ± 0.8 1.1 ± 0.7 1.1 ± 0.9 0.87
CMR findings
Maximum wall delay (ms) 432 ± 120 455 ± 104 404 ± 135 0.23
Type II pattern, n (%) 20 (61) 14 (78) 6 (40) 0.038
Septal flash, n (%) 27 (82) 17 (94) 10 (67) 0.07
No scar, n (%) 25 (76) 16 (89) 9 (60) 0.10
Concordant CRT lead, n (%) 18 (55) 13 (72) 5 (28) 0.038
Combined type II pattern and concordant CRT lead, n (%) 12 (36) 11 (61) 1 (7) 0.003
  1. aA favorable ECG pattern is indicated by the presence of a true left bundle branch block and a QRS duration > 150 ms
  2. Values are presented as n (%) or mean ± standard deviation. ACE = Angiotensinogen Converting Enzyme; ARB = Angiotensin Receptor Blocker; CMR = Cardiovascular Magnetic Resonance; CRT = Cardiac Resynchronization Therapy; ECG = Electrocardiogram; LBBB = Left Bundle Branch Block; NYHA = New York Heart Association; NICM = Non-Ischemic Cardiomyopathy