Table 1 Patient characteristics
All Patients | Responders | Non-responders | P value | |
|---|---|---|---|---|
N = 33 | N = 18 (55 %) | N = 15 (45 %) | ||
Age (years) | 61 ± 13 | 61 ± 13 | 62 ± 12 | 0.72 |
Male, n (%) | 18 (55) | 7 (39) | 11 (73) | 0.08 |
NICM, n (%) | 26 (79) | 17 (94) | 9 (60) | 0.03 |
NHYA functional class | 2.8 ± 0.4 | 2.8 ± 0.4 | 2.8 ± 0.4 | 0.86 |
Comorbidities, n (%) | ||||
Coronary artery disease | 10 (30) | 2 (11) | 8 (53) | 0.02 |
Diabetes mellitus | 9 (27) | 5 (28) | 4 (27) | 0.94 |
Hypertension | 16 (49) | 8 (44) | 8 (53) | 0.73 |
Dyslipidemia | 17 (52) | 8 (44) | 9 (60) | 0.49 |
Chronic kidney disease | 7 (21) | 3 (17) | 4 (27) | 0.67 |
Atrial fibrillation | 7 (21) | 4 (22) | 3 (20) | 0.88 |
Medications, n (%) | ||||
ACE inhibitor/ARB | 32 (97) | 18 (100) | 14 (93) | 0.46 |
Beta-blocker | 32 (97) | 18(100) | 14 (93) | 0.46 |
Aldosterone antagonist | 11 (33) | 6 (33) | 5 (33) | 1.00 |
Diuretic | 23 (70) | 13 (72) | 10 (67) | 0.73 |
Statin | 18 (55) | 8 (44) | 10 (67) | 0.30 |
Clinical variables | ||||
Body mass index (kg/m2) | 28 ± 5 | 29 ± 4 | 28 ± 6 | 0.89 |
Resting heart rate (bpm) | 73 ± 14 | 75 ± 17 | 71 ± 10 | 0.42 |
Serum creatinine (mg/dl) | 1.06 ± 0.24 | 1.06 ± 0.24 | 1.07 ± 0.26 | 0.90 |
Favorable ECG patterna, n (%) | 13 (39) | 9 (50) | 4 (27) | 0.28 |
Echocardiographic variables | ||||
End-systolic volume (ml) | 150 ± 71 | 143 ± 61 | 159 ± 84 | 0.55 |
Ejection fraction (%) | 28 ± 9 | 27 ± 8 | 30 ± 9 | 0.37 |
Mitral regurgitation grade | 1.1 ± 0.8 | 1.1 ± 0.7 | 1.1 ± 0.9 | 0.87 |
CMR findings | ||||
Maximum wall delay (ms) | 432 ± 120 | 455 ± 104 | 404 ± 135 | 0.23 |
Type II pattern, n (%) | 20 (61) | 14 (78) | 6 (40) | 0.038 |
Septal flash, n (%) | 27 (82) | 17 (94) | 10 (67) | 0.07 |
No scar, n (%) | 25 (76) | 16 (89) | 9 (60) | 0.10 |
Concordant CRT lead, n (%) | 18 (55) | 13 (72) | 5 (28) | 0.038 |
Combined type II pattern and concordant CRT lead, n (%) | 12 (36) | 11 (61) | 1 (7) | 0.003 |