Skip to main content

Table 2 Overview of cited pre-clinical animal studies

From: The diagnostic value of iron oxide nanoparticles for imaging of myocardial inflammation – quo vadis?

Object of study

 

Field-strength B0 in T

# Animals

Dose in mg Fe/kg

Average particle size in nm

Coating

Half-life in h*

Relaxivites in mM−1 s−1

Myocardial infarct

Chapon et al. 2003 [50],

7.0

42

1, 5, 10

50

Dextran

0.8

R1 = 1.2, R2 = 24; (7 T)

Sosnovik et al. 2007 [51],

9.4

21

3, 10, 20

32

Cross-linked dextrans

10

 

Montet-Abou et al. 2009 [52],

1.5

44

10

15

Polymer

6

 

Protti et al. 2014 [53],

7.0

73

15

7

Citrate

2

R1 = 30, R2 = 39; (0,47 T)

Myocarditis

Moon et al. 2012 [54],

4.7

90

10

85

Silica

2.8

R2 = 130; (4,7 T)

  1. Overview of cited pre-clinical animal studies, including particle doses used and physical properties - partially adapted from MICAD [40]. * half-life in rodent blood