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Table 3 Adverse Reactions Categorized by Agents Specific Characteristics

From: 2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry

Agent

Molecular Structure

I Ionic / Non-Ionic

Log Ktherm

Reactions (%)

Gadopentetate (e.g. Magnevist)

Linear

Ionic

22.1

0.16

Gadoteracid (e.g. Dotarem)

Cyclic

Ionic

25.8

0.12

Gadobenat (e.g. Multihance)

Linear

Ionic

22.6

0.42

Gadobutrol (e.g. Gadovist)

Cyclic

Non-Ionic

21.8

0.10

Gadoteridol (e.g. Prohance)

Cyclic

Non-Ionic

23.8

0.19

Gadodiamide (e.g. Omniscan)

Linear

Non-Ionic

16.9

0.05

Others

N/A

N/A

N/A

N/A

  1. Log Ktherm, chelate stability; N/A, non applicable