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Table 3 Diagnostic accuracy of a multi-parametric CMR exam and its individual components, paired and triplet combinations compared to the reference test X-ray angiography

From: Individual component analysis of the multi-parametric cardiovascular magnetic resonance protocol in the CE-MARC trial

 

Sensitivity (95 % CI)

Specificity (95 % CI)

PPV (95 % CI)

NPV (95 % CI)

Overall accuracy (95 % CI)

Overall multi-parametric CMR study (all components) (n = 676)

86.5 (81.8, 90.1)

83.4 (79.5, 86.7)

77.2 (72.1, 81.6)

90.5 (87.1, 93.0)

84.6 (81.7, 87.1)

Individual CMR components

     

LGE (n = 674)

40.8 (35.0, 46.8)

95.8 (93.4, 97.4)

86.4 (79.3, 91.3)

71.4 (67.5, 75.0)

74.2 (70.7, 77.3)

Perfusion (n = 661)

76.9 (71.4, 81.6)

91.8 (88.7, 94.1)

85.8 (80.8, 89.7)

86.0 (82.4, 89.0)

85.9 (83.1, 88.4)

Ventricular function (n = 676)

47.4 (41.4, 53.4)

93.7 (90.9, 95.6)

82.9 (76.1, 88.1)

73.3 (69.3, 76.9)

75.4 (72.1, 78.5)

MRA (n = 597)

71.2 (65.1, 76.7)

89.8 (86.3, 92.5)

81.8 (75.9, 86.5)

83.0 (79.0, 86.4)

82.6 (79.3, 85.4)

Paired combinations

     

Perfusion/LGE (n = 676)

78.6 (73.3, 83.1)

89.3 (85.9, 91.9)

82.6 (77.5, 86.8)

86.5 (82.9, 89.5)

85.1 (82.2, 87.5)

Perfusion/function (n = 676)

80.1 (74.9, 84.4)

87.3 (83.7, 90.2)

80.4 (75.2, 84.7)

87.1 (83.5, 90.0)

84.5 (81.5, 87.0)

Perfusion/MRA (n = 676)

82.3 (77.3, 86.4)

89.0 (85.6, 91.7)

83.0 (78.0, 87.0)

88.6 (85.2, 91.3)

86.4 (83.6, 88.8)

Function/LGE (n = 676)

52.6 (46.6, 58.6)

91.7 (88.6, 94.0)

80.5 (73.9, 85.7)

74.9 (70.9, 78.5)

76.3 (73.0, 79.4)

Function/MRA (n = 676)

72.9 (67.3, 77.9)

87.8 (84.3, 90.6)

79.5 (74.0, 84.1)

83.3 (79.5, 86.6)

82.0 (78.9, 84.7)

LGE/MRA (n = 676)

69.2 (63.4, 74.4)

90.0 (86.7, 92.5)

81.8 (76.2, 86.3)

81.8 (78.0, 85.1)

81.8 (78.7, 84.5)

Triplet combinations

     

Perfusion/LGE/function (n = 676)

81.6 (76.5, 85.8)

85.9 (82.1, 88.9)

78.9 (73.7, 83.3)

87.8 (84.2, 90.6)

84.2 (81.2, 86.7)

Perfusion/LGE/MRA (n = 676)

84.6 (79.8, 88.4)

86.6 (82.9, 89.5)

80.4 (75.3, 84.6)

89.6 (86.3, 92.3)

85.8 (83.0, 88.2)

Perfusion/function/MRA (n = 676)

85.3 (80.6, 89.1)

84.9 (81.1, 88.0)

78.5 (73.5, 82.9)

89.9 (86.5, 92.5)

85.1 (82.2, 87.5)

LGE/function/MRA (n = 676)

75.2 (69.7, 80.0)

86.1 (82.4, 89.1)

77.8 (72.4, 82.5)

84.2 (80.5, 87.4)

81.8 (78.7, 84.5)

  1. CMR cardiovascular magnetic resonance, LGE late gadolinium enhancement, LR- Likelihood Ratio Negative, LR+ Likelihood Ratio Positive, MRA magnetic resonance coronary angiography