Fig. 3
Myocardial and hepatic steatosis assessed with 1H-MRS. Hepatic (a) and myocardial (b) fat were followed-up during 4 months. Myocardial and hepatic steatosis were inter-correlated at M4 (c), and correlated to weight, glycemia and area under the curve (AUC) of glucose at M4. Volume of interest was positioned in the anterior part of the liver for hepatic triglyceride content quantification (d), and in the interventricular septum for myocardial triglyceride content quantification (e). PRESS sequence was applied to determine molecular content of water and triglyceride. Chemical shifts appear at 4.7 ppm in the spectra for water, and 1.3 ppm for triglycerides. AMARES algorithm fitting peak line shape has been used for spectra analysis (f). Two-way Anova test with repeated measures has been performed to assess differences. Data are mean ± SEM. *P < 0,05; **p < 0,005; ***p < 0,0005 vs SD