Skip to main content
Fig. 7 | Journal of Cardiovascular Magnetic Resonance

Fig. 7

From: Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance

Fig. 7

Four months diet effects on metabolic and cardiac parameters were significantly reversed by Ex-4 treatment. Intraperitoneal Glucose tolerance test showed elevated AUC glucose (ai, bi) and fasting plasma glucose (ci) after M4 of HFHSD. Ex-4 significantly improved glucose secretion compared to placebo mice (aii, aiii, bii, biii) and reduced fasting plasma glucose in both placebo (cii), and Ex-4 groups (ciii). Ex-4 treatment induced significant weight loss in both placebo (dii) and Ex-4 groups (diii) as well. Cardiac and hepatic fat accumulations are increased in obese mice (ei, fi) and short duration of Ex-4 treatment dramatically reduced both ectopic lipid accumulation (eiii, fiii) whereas no change was observed in saline-treated mice (eii, fii). However, Ex-4 treatment had no effect on plasma triglyceride levels (gii, giii) albeit significant increase 4-month post-diet in HFHSD group (gi). Cardiac parameters altered with HFHSD (hi, ii, ji) are significantly corrected after Ex-4 treatment (hiii, liii, jiii) but not after saline treatment (hii, lii, jii). sWthD: Septum wall thickness, sFS: Septum fractional shortening, CI: Cardiac index. HFHSD mice displayed hypoperfusion at 4-month (ki) which is completely corrected after Ex-4 treatment (kiii) compared to placebo group (kii). Data are presented as means ± SEM. Treatment effect on AUC glucose during IPGTTT was assessed using Two-way ANOVA test. Other parameters were statistically assessed with paired t-test or Wilcoxon signed rank test when values were not normally distributed. *p <0,05; **p <0,005; ***p <0,0005

Back to article page