Table 1 Baseline characteristics

    n (%)

3’647 (100 %)

1’786 (49.0 %)

582 (16.0 %)

-

    Male (%)^†

58.7 %

45.7 %

42.8 %

<0.001

    Age at baseline (y); mean (range) ^‡

61.6 (14–92)

61.1 (14–92)

62.6 (26–88)

<0.05

    Weight (kg); mean (range) ^§

80.4 (28–183)

80.2 (30–183)

79.7 (28–182)

ns

    Hypertension ^§

ns

      - none

38.1 %

39.1 %

35.4 %

      - treated

58.1 %

56.7 %

60.3 %

      - untreated

3.9 %

4.3 %

4.3 %

    Dyslipidemia ^ǁ

42.2 %

40.5 %

45.9 %

0.059

    Diabetes mellitus ^ǁ

13.3 %

10.8 %

15.0 %

<0.001

    Smoker ^ǁ

ns

      - No

74.5 %

73.9 %

73.9 %

      - Current

12.9 %

12.9 %

13.8 %

      - Previous

12.7 %

13.2 %

12.4 %

    Family history of CAD ^§

27.0 %

28.3 %

29.4 %

<0.05

      - Patient complaints

72.7 %

89.7 %

89.7 %

<0.001

      - Presence of cardiovascular risk factors

55.9 %

53.4 %

53.1 %

<0.001

      - Ambiguous Stress ECG

20.2 %

17.4 %

14.4 %

<0.001

      - Ambiguous Stress Echocardiography

1.9 %

1.4 %

1.2 %

<0.01

      - Ambiguous Stress SPECT

0.3 %

0.2 %

0.5 %

ns

      - Ambiguous Cardiac CT

0.9 %

0.7 %

0.5 %

ns

    Revascularizations

226 (6.2 %)

81 (4.5 %)

75 (12.9 %)

<0.001

    - PCI only

179 (4.9 %)

70 (3.9 %)

53 (9.1 %)

<0.001

    - CABG only

41 (1.1 %)

10 (0.6 %)

19 (3.3 %)

<0.001

    - PCI and CABG

6 (0.2 %)

1 (0.1 %)

3 (0.5 %)

0.059

    Primary endpoint

75 (2.1 %)

33 (1.9 %)

11 (1.9 %)

ns

    - Mortality : all cause

34 (0.9 %)

15 (0.8 %)

7 (1.2 %)

ns

    - Cardiac death

7 (0.2 %)

6 (0.4 %)

0 (0.0 %)

ns

    - Cardiac death and unknown cause

23 (0.6 %)

13 (0.7 %)

2 (0.3 %)

ns

    - Non-fatal myocardial infarction

11 (0.3 %)

5 (0.2 %)

2 (0.3 %)

ns

    - Aborted sudden cardiac death

8 (0.3 %)

4 (0.2 %)

1 (0.2 %)

ns

    - Stroke

18 (0.5 %)

10 (0.6 %)

1 (0.2 %)

ns