Table 2 Comparison of typical major cardiovascular features between humans and rodents. The values for rats and mice are average values typical for animals under isoflurane anesthesia. The differences in blood recirculation time and capillary blood flow have strong impact on the choice of methods for measuring perfusion

Body weight

80 kg

0.3 kg

0.03 kg

Total blood volume

5 L

18 mL

1.8 mL

End diastolic volume (EDV)

180 mL

300 μL

50 μL

Myocardial Mass

150 g

0.6 g

0.1 g

Heart Rate

80 bpm

300 bpm

600 bpm

Cardiac Output

5 L/min

0.15 L/min

0.020 L/min

Time of recirculation

60 s

7 s

5 s

Aortic ejection velocity [101–103]

100 cm/s

200 cm/s

300 cm/s

Breathing rate

12 bpm

70 bpm

110 bpm

Myocardial perfusion (MBF)

1 mL/g/min

5 mL/g/min

7 mL/g/min