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Table 1 Baseline Differences Between Cardiac Normal healthy, AL-CA patients with or without LV systolic dysfunction

From: Regional myocardial microvascular dysfunction in cardiac amyloid light-chain amyloidosis: assessment with 3T cardiovascular magnetic resonance

 

Normal subjects (n = 25)

CA without SD (n = 21)

CA with SD (n = 11)

Age (Y)

37.68 ± 11.94

60.10 ± 7.85*

59.82 ± 12.14*

Male

13 (52)

11 (52)

6 (55)

NYHA functional class

   

I

-

2 (9)

0 (0)

II

-

10 (48)

4 (36)

III

-

9 (43)

5 (46)

IV

-

0 (0)

2 (18)

Echocardiography

   

Septal thickness (mm)

8.73 ± 1.55

15.29 ± 2.83*

17.27 ± 2.57*

E/A

1.2 ± 0.2

1.7 ± 0.6*

2.4 ± 0.8*§

E/E’

11.11 ± 2.21

17.14 ± 4.33*

20.82 ± 5.69*§

Cine-CMR

   

LVEDV (ml)

133.78 ± 25.43

111.06 ± 26.84*

118. 20 ± 24.47

LVESV (ml)

52.62 ± 14.01

47.45 ± 12.97

71.95 ± 17.71*§

LV SV (ml)

81.18 ± 15.29

63.60 ± 23.44*

46.25 ± 10.78*§

LVEF (%)

60.18 ± 4.30

56.62 ± 9.43

39.28 ± 6.39*§

LV mass (g)

85.32 ± 23.32

127.14 ± 32.29*

143.55 ± 42.64*

Pericardial effusion

-

12 (57)

4 (36)

Pleural effusion

-

13 (67)

7 (63)

  1. Notes: The values are the mean ± SD, Numbers in the brackets are percentages. * P < 0.017 versus normal group; § P < 0.0017 versus CA with preserved LVEF. AL-CA = light-chain amyloid cardiac amyloidosis; SD = systolic dysfunction; LV = left ventricular; EDV = end diastolic volume; ESV = end systolic volume; EF = ejection fraction; SV = stroke volume