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Table 1 Serial blood cobalt and chromium levels with concurrent myocardial and hepatic T2*

From: Detection of metallic cobalt and chromium liver deposition following failed hip replacement using T2* and R2 magnetic resonance

 

Scan Date (month/year)

LVEF (%)

EDV (ml)

ESV (ml)

Mass (g)

Cardiac T2* (ms) (LLN 20 ms)

Liver T2* (ms) (LLN 6.3 ms)

Equivalent liver iron concentration using FerriScan R2 (mg/g/dry tissue)

Blood Co (ULN 0.9mcg/L)

Blood Cr (ULN <0.3mcg/L)

1

Apr-14

68

142

46

127

29

4.2

3.9

9976

393

2

Oct-14

66

139

47

122

24

3.3

5.6

392

200

3

Jan-15

60

143

58

129

36

3

5.3

276

192

4

Jun-15

65

145

51

113

27

2.9

5.3

151

132

  1. Myocardial T2* values were normal. Short hepatic T2* values (normal greater than 6.2 ms) indicate the presence of metal. Despite falling blood metal ion levels, liver MR results suggested increasing tissue deposition. Ferriscan measurements demonstrate the detectable signal change and iron equivalent for an iron-loaded patient. (LLN lower limit of normal, ULN upper limit of normal)