Variables | Death/Transplant/Worse NYHA (nā=ā78) | No endpoint (nā=ā32) | P |
---|---|---|---|
Clinical, CMR and hemodinamics variables | |||
Age (yrs) | 53āĀ±ā12 | 50āĀ±ā12 | 0.35 |
Sex (female) | 54 (69.2Ā %) | 27 (84.4Ā %) | 0.15 |
Body surface area (m2) | 1.8āĀ±ā0.25 | 1.7āĀ±ā0.22 | 0.45 |
Use of medication | 71 (91Ā %) | 10 (31Ā %) | <0.001 |
Smoking | 5 (6.4Ā %) | 3 (9.4Ā %) | 0.059 |
NYHA class ā„2 | 71 (91Ā %) | 3 (9.3Ā %) | <0.001 |
Systolic aortic pressure (mm Hg) | 119āĀ±ā18 | 127āĀ±ā20.5 | 0.03 |
PAWP (mm Hg) | 9.7āĀ±ā4.2 | 10.1āĀ±ā4.7 | 0.38 |
Cardiac index (L/min/m2) | 3āĀ±ā1 | 3.6āĀ±ā1.57 | 0.04 |
Systolic PA pressure (mm Hg) | 73.2āĀ±ā20.3 | 58.1āĀ±ā19.1 | 0.004 |
Mean PA pressure (mm Hg) | 44.6āĀ±ā11.8 | 27.5āĀ±ā12.2 | <0.001 |
RA pressure | 9.4āĀ±ā7.9 | 6.4āĀ±ā3.0 | 0.18 |
PVRI (Woods units x m2) | 6.6 [3.9ā10.3] | 2.4 [1.5ā6.8] | 0.004 |
PA sat (%) | 62āĀ±ā11.6 | 71āĀ±ā4.8 | 0.002 |
LVEF (%) | 56.9āĀ±ā10.8 | 62.5āĀ±ā5.5 | <0.001 |
LVEDVi (mL/m2) | 64āĀ±ā18 | 72āĀ±ā14 | 0.036 |
LVESVi (mL/m2) | 27.7āĀ±ā10.9 | 27.3āĀ±ā6.7 | 0.82 |
RVEF (%) | 37.38āĀ±ā12.4 | 53.7āĀ±ā9.4 | <0.001 |
RVEDVi (mL/m2) | 112 [87.6ā144.6] | 75 [69.9ā97.9] | 0.01 |
RVESVi (mL/m2) | 70 [44.9ā95.4] | 35.2 [28.7ā48.3] | <0.001 |
RV mass index (gr/m2) | 29.8 [23.5ā35.1] | 18.4 [14.3ā22.9] | 0.001 |
LGE | 39 (50Ā %) | 5 (15.6Ā %) | 0.01 |
RA area | 26āĀ±ā9.4 | 20āĀ±ā5.8 | 0.001 |
Strain parameters | |||
GLS (%) | - 13.57āĀ±ā5.5 | -19.01āĀ±ā5.7 | <0.001 |
GCS (%) | -9.6āĀ±ā4.2 | -12.58āĀ±ā3.7 | 0.007 |
GLSR (s-1) | -0.94āĀ±ā0.3 | -1.33āĀ±ā0.4 | <0.001 |
GCSR (s-1) | -0.67 [-0.7 - (-0.4)] | -0.92 [-1.1 - (-0.8)] | <0.001 |