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Statistical analysis/ Model
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Per vessel
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Per patient
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|---|
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Fermi
|
DP
|
Fermi
|
DP
|
|---|
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P values from t-test comparisons
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|
MBF (G1 vs G2)
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0.02*
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<0.0001 †
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<0.00001*
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<0.00001 †
|
|
MPR (G1 vs G2)
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<0.01*
|
<0.0001 †
|
<0.00001*
|
<0.00001 †
|
|
MPR2 (G1 vs G2)
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<0.00001*
|
<0.00001 †
|
<0.00001*
|
<0.00001 †
|
|
AUCs from ROC analysis
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|
MBF
|
0.68 (0.55, 0.80)
|
0.76 (0.65, 0.87)
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0.86 (0.77, 0.94)
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0.97 (0.92, 1.00)
|
|
MPR
|
0.69 (0.56, 0.81)
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0.79 (0.68, 0.89)
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0.85 (0.75, 0.94)
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0.94 (0.87, 1.00)
|
|
MPR2
|
0.77 (0.66, 0.88)
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0.82 (0.72, 0.92)
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0.88 (0.80, 0.96)
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0.96 (0.91, 1.00)
|
|
Thresholds on ROC analysis
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|
MBF (mL/min/mL)
|
2.49
|
1.75
|
2.60
|
2.00
|
|
MPR
|
1.76
|
1.45
|
1.88
|
1.59
|
|
MPR2
|
1.36
|
1.07
|
1.49
|
1.47
|
|
P values from comparisons of ROC curves between haemodynamic parameters
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|
MBF vs MPR
|
0.81
|
0.54
|
0.80
|
0.35
|
|
MBF vs MPR2
|
0.04*
|
0.19
|
0.45
|
0.68
|
|
MPR vs MPR2
|
0.0022*
|
0.20
|
0.17
|
0.33
|
|
Difference in AUC of ROC curves between haemodynamic parameters
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|
MBF vs MPR
|
-0.01 (-0.10, 0.08)
|
-0.03 (-0.11, 0.05)
|
0.01 (-0.06, 0.08)
|
0.03 (-0.03, 0.09)
|
|
MBF vs MPR2
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-0.09 (-0.18, 0.01)
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-0.06 (-0.14, 0.02)
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-0.03 (-0.10, 0.04)
|
0.01 (-0.04, 0.06)
|
|
MPR vs MPR2
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-0.08 (-0.16, 0.01)
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-0.03 (-0.09, 0.02)
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-0.04 (-0.09, 0.01)
|
-0.02 (-0.06, 0.02)
|
- Statistically significant differences are indicated with * and † († show at least two orders of magnitude smaller P values compared to *, both in per vessel and per patient analysis). Parentheses show (95 % confidence intervals). MBF myocardial blood flow, MPR myocardial perfusion reserve, MPR
2
myocardial perfusion reserve of the two lowest scoring segments, AUC area under the curve, DP distributed parameter modeling, G1 Group 1, G2 Group 2
