A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance—the T1 Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program

Captur, Gabriella; Gatehouse, Peter; Keenan, Kathryn E.; Heslinga, Friso G.; Bruehl, Ruediger; Prothmann, Marcel; Graves, Martin J.; Eames, Richard J.; Torlasco, Camilla; Benedetti, Giulia; Donovan, Jacqueline; Ittermann, Bernd; Boubertakh, Redha; Bathgate, Andrew; Royet, Celine; Pang, Wenjie; Nezafat, Reza; Salerno, Michael; Kellman, Peter; Moon, James C.

doi:10.1186/s12968-016-0280-z

Journal of Cardiovascular Magnetic Resonance

Table 3 Short-term reproducibility experiments in a 3 T final phantom (E-model)*

From: A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance—the T₁ Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program

Tube	Parameter	Sequence	CoV (%)	Mean diff. ± s.d.
A	T₁	pre_MOLLI_5(3)3_256_T1	0.16	255 ± 0.4
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.18	255 ± 0.5
	T₂	T2_4pt_TRUFI_192i_T2	0.66	194 ± 1.3
	T₂	T2_4pt_GRE_192i_T2	0.61	134 ± 0.8
J	T₁	pre_MOLLI_5(3)3_256_T1	0.14	1860 ± 2.6
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.17	1672 ± 2.8
	T₂	T2_4pt_TRUFI_192i_T2	4.06	227 ± 9.2
	T₂	T2_4pt_GRE_192i_T2	1.37	203 ± 2.8
C	T₁	pre_MOLLI_5(3)3_256_T1	0.08	460 ± 0.4
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.08	461 ± 0.4
	T₂	T2_4pt_TRUFI_192i_T2	0.52	195 ± 1.0
	T₂	T2_4pt_GRE_192i_T2	0.76	160 ± 1.2
K	T₁	pre_MOLLI_5(3)3_256_T1	0.13	953 ± 1.2
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.10	917 ± 0.9
	T₂	T2_4pt_TRUFI_192i_T2	0.98	60 ± 0.6
	T₂	T2_4pt_GRE_192i_T2	0.67	49 ± 0.3
L	T₁	pre_MOLLI_5(3)3_256_T1	0.08	1372 ± 1.1
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.16	1252 ± 2.0
	T₂	T2_4pt_TRUFI_192i_T2	0.91	56 ± 0.5
	T₂	T2_4pt_GRE_192i_T2	0.89	49 ± 0.4
M	T₁	pre_MOLLI_5(3)3_256_T1	0.15	1178 ± 1.8
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.12	1104 ± 1.3
	T₂	T2_4pt_TRUFI_192i_T2	0.91	58 ± 0.5
	T₂	T2_4pt_GRE_192i_T2	0.66	49 ± 0.3
G	T₁	pre_MOLLI_5(3)3_256_T1	0.19	285 ± 0.6
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.20	285 ± 0.6
	T₂	T2_4pt_TRUFI_192i_T2	0.29	86 ± 0.2
	T₂	T2_4pt_GRE_192i_T2	1.02	49 ± 0.5
H	T₁	pre_MOLLI_5(3)3_256_T1	0.11	527 ± 0.6
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.09	527 ± 0.5
	T₂	T2_4pt_TRUFI_192i_T2	0.35	66 ± 0.2
	T₂	T2_4pt_GRE_192i_T2	0.72	46 ± 0.3
I	T₁	pre_MOLLI_5(3)3_256_T1	0.06	406 ± 0.3
	T₁	post_MOLLI_4(1)3(1)2_256_MOCO_T1	0.05	409 ± 0.2
	T₂	T2_4pt_TRUFI_192i_T2	0.21	72 ± 0.2
	T₂	T2_4pt_GRE_192i_T2	0.19	47 ± 0.1

*All tests performed at 20.3 ± 0.48 °C on Siemens, Skyra 3 T at RBHT, November 2015 with RR interval 900 ms and using two T₁ mapping sequences (pre-MOLLI 5(3)3 [256] and post-MOLLI 4(1)3(1)2 [256] with MOCO, WIPs# 780B) and two T₂ mapping sequences (TRUFI T2 map and GRE T2 map)
CoV coefficients of variation, diff. difference, GRE gradient echo, MOCO motion correction, MOLLI modified Look-Locker inversion recovery, RR inter-beat interval, s.d. standard deviation, TRUFI true fast imaging with steady-state free precession

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