Fig. 2
From: Ventricular structure in ARVC: going beyond volumes as a measure of risk
The statistical analysis framework to analyse the anatomical differences between ARVC patients and asymptomatic control subjects by considering the mean (average) anatomy as the model of interest and describing all other subjects as a deformation of this model. The subject-specific deformations can be analysed to extract dominant anatomical features in the population (modes), as well as studying the relationship between the anatomical features and clinical diagnostic parameters. A real-world example is shown by considering the geography of the earth, representing this in 3D with a scale model (a globe), projecting this to 2D (a map), and extracting dominant geographical features such as altitude, to correlate with an external geographical parameter (temperature for example)