Native T1 values identify myocardial changes and stratify disease severity in patients with Duchenne muscular dystrophy

Table 4 Native T1 and ECV values for subjects with DMD and normal controls

Technique	Location	Measurement	DMD^a	DMD^a	Control	Control	p
Technique	Location	Measurement	Average	SD	Average	SD	p
MOLLI	Septal	Native T1	1046.1	61.1	989.9	33.5	0.000
	Septal	ECV^b	27.9	5.8	26.0	3.3	0.047
	Lateral	Native T1	1075.1	71.8	978.2	36.4	0.000
	Lateral	ECV^b	31.3	6.7	24.4	3.5	0.000
SASHA	Septal	Native T1	1233.6	66.8	1133.6	72.0	0.000
	Septal	ECV^b	23.6	4.3	20.0	2.6	0.008
	Lateral	Native T1	1268.6	78.2	1135.8	144.2	0.001
	Lateral	ECV^b	27.5	6.5	21.4	2.3	0.000

Native T1 and ECV values for subjects with DMD and normal controls in the septal and lateral locations, using both the MOLLI and SASHA techniques for measuring T1. Septal myocardial values of ECV are significantly different between DMD and control subjects, using both imaging methods. In this cohort of boys with DMD, all LGE was contained to the septum, thus this finding represents a significant difference in myocardium that does not have overt fibrosis on LGE imaging.^aDMD Duchenne muscular dystrophy, ^bECV extracellular volume fraction

ISSN: 1532-429X