Fig. 1

a Transverse T1-weighted spin-echo CMR of the thigh musculature in a patient with late-onset Pompe disease (LOPD). The adductor and ischiocrural muscles show symmetrical and confluent hyperintensity indicative of severe fibrosis and lipodystrophy (red stars). Some patchy fatty replacement can also be seen in the vastus lateralis muscles (yellow arrows) and, to a much lesser extent, in the vastus medialis muscles (blue arrows). b–c Short and long-axis late gadolinium enhancement (LGE) CMR images of the same patient showing no myocardial involvement (no fibrosis, no fatty replacement)