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Table 3 Inter-observer variability in three observers with different level of expertise

From: Cardiovascular magnetic resonance myocardial feature tracking using a non-rigid, elastic image registration algorithm: assessment of variability in a real-life clinical setting

  Inter-observer # Expert versus Skilled Observer Expert versus Beginner
  Bias LOA CV CR ICC (95% CI) Bias LOA CV CR ICC (95% CI)
Healthy Volunteer Global ErrSAX 120 0.01 [−3.3;3.4] 4.3 ±4.8 0.97 (0.97–0.98) −0.61* [−6.8;5.6] 8.3 ±8.8 0.99 (0.98–0.99)
EccSAX 120 0.46* [−1.5;2.5] 5.4 ±2.9 0.98 (0.98–0.98) −0.34* [−2.9;2.3] 6.9 ±3.7 0.98 (0.97–0.99)
EllLAX 20 0.50* [−0.7;1.7]£ 4.0 ±1.7 0.85 (0.46–0.95) 0.70* [−2.4;3.8]£ 5.3 ±2.2 0.74 (0.45–0.89)
Segm. ErrSAX 660 0.01 [−8.8;8.8]£ 16.4 ±12.4 0.96 (0.96–0.96) −0.43 [−11.8;10.9]£ 22.9 ±16.0 0.95 (0.94–0.95)
EccSAX 660 0.55* [−5.6;6.7]£ 17.1 ±8.7 0.95 (0.94–0.96) −0.22 [−10.2;9.8]£ 22.7 ±14.2 0.92 (0.91–0.93)
EllLAX 140 0.60* [−5.3;6.5]£ 18.7 ±8.3 0.90 (0.86–0.93) 0.86* [−8.4;10.1]£ 19.6 ±13.1 0.80 (0.76–0.90)
Normal Group Global ErrSAX 87 0.57* [−2.7;3.8] 5.7 ±4.6 0.97 (0.97–0.97) 0.19 * [−3.4;3.8] 7.3 ±5.1 0.97 (0.96–0.97)
EccSAX 87 0.56* [−1.3;2.4] 5.2 ±2.6 0.99 (0.98–0.99) −0.16 [−1.8;1.4] 5.0 ±2.2 0.99 (0.98–0.99)
EllLAX 20 −0.03 [−1.5;1.5] 4.4 ±2.2 0.89 (0.73–0.95) 0.29* [−1.4;2.0] 5.2 ±2.4 0.91 (0.87–0.96)
Segm. ErrSAX 470 0.57* [−8.8;9.9]§£ 21.3 ±13.2 0.92 (0.89–0.95) 0.14 [−10.6;10.9]§£ 21.8 ±15.2 0.92 (0.91–0.94)
EccSAX 470 0.55* [−4.4;5.5] 15.0 ±7.0 0.96 (0.96–0.97) −0.18 [−5.5;5.1]£ 17.3 ±7.5 0.94 (0.93–0.95)
EllLAX 140 −0.17 [−4.5;4.2] 19.4 ±6.2 0.89 (0.85–0.92) 0.18 [−5.2;5.5]§ 19.7 ±7.5 0.90 (0.86–0.92)
Patient Group Global ErrSAX 86 0.26 [−3.2;3.7] 8.6 ±4.9 0.97 (0.97–0.99) 0.09 [−2.8;3.0] 6.7 ±4.1 0.99 (0.98–0.99)
EccSAX 86 0.51* [−1.0;2.0] 6.0 ±2.2 0.99 (0.96–0.99) 0.13 [−1.5;1.7] 6.2 ±2.2 0.98 (0.97–0.99)
EllLAX 18 0.71* [−1.2;2.7] 7.9 ±3.7 0.97 (0.85–0.99) −0.15 [−2.5;2.2] 7.9 ±3.3 0.97 (0.88–0.99)
Segm. ErrSAX 470 0.26 [−8.2;8.7]§£ 25.2 ±11.9 0.93 (0.90–0.95) 0.13 [−8.6;8.9]§£ 23.9 ±12.4 0.92 (0.88-0.95)
EccSAX 470 0.63* [−4.5;5.8]£ 19.4 ±7.3 0.95 (0.94–0.96) 0.14 [−4.9;5.2]£ 21.0 ±7.2 0.95 (0.93-0.96)
EllLAX 126 0.65* [−5.7;7.0] 24.8 ±9.0 0.92 (0.88–0.94) 0.44* [−6.1;7.0]§ 25.7 ±9.3 0.90 (0.88–0.94)
  1. # - Sample Size, LOA Limits of agreement; CV Coefficient of variation (%); CR Coefficient of repeatability; ICC Intraclass correlation coefficient; CI Coefficient Interval
  2. *p < 0.05, two tailed paired t-test against zero
  3. § p < 0.05, two tailed F-test between patient group and normal group for each strain component
  4. £ p < 0.05, two tailed F-test between the results obtained by the different observers (expert vs skilled observer, and expert versus beginner)