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Table 4 Inter-study variability in the healthy volunteer

From: Cardiovascular magnetic resonance myocardial feature tracking using a non-rigid, elastic image registration algorithm: assessment of variability in a real-life clinical setting

Inter-study

#

Bias

LOA

CV

CR

ICC (95% CI)

Expert

Global

ErrSAX

120

1.34*

[−7.1;9.8]£

22.0

±12.0

0.87 (0.74–0.95)

EccSAX

120

0.26

[−2.3;2.9]

13.5

±3.7

0.90 (0.79–0.97)

EllLAX

20

−1.79*

[−3.3;-0.3]£

9.6

±2.1

0.52 (0.10–1.00)

Segm.

ErrSAX

660

−0.23

[−11.8;11.4]

30.7

±16.4

0.86 (0.80–0.91)

EccSAX

660

1.02*

[−4.3;6.3]

26.8

±7.5

0.84 (0.78–0.89)

EllLAX

140

0.66*

[4.8;6.1]£

33.4

±7.7

0.60 (0.41–0.81)

Skilled Observer

Global

ErrSAX

120

1.53*

[−7.2;10.3]

22.8

±12.4

0.86 (0.72–0.95)

EccSAX

120

0.08

[−2.8;3.0]

15.5

±4.1

0.88 (0.77–0.96)

EllLAX

20

−1.56*

[−3.2;0.1]

10.4

±2.3

0.50 (0.08–1.00)

Segm.

ErrSAX

660

−0.29

[−11.0;10.4]$

28.3

±15.1

0.87 (0.81–0.91)

EccSAX

660

0.95*

[−4.0;5.9]

25.7

±7.0

0.87 (0.83–0.91)

EllLAX

140

0.86*

[−4.2;6.0]

32.2

±7.3

0.60 (0.40–0.80)

Beginner

Global

ErrSAX

120

0.83

[−8.5;10.1]£

24.6

±13.1

0.84 (0.69–0.94)

EccSAX

120

0.13

[−3.0;3.3]

16.0

±4.5

0.88 (0.76–0.96)

EllLAX

20

−2.06*

[−4.2;0.1]£

13.7

±3.1

0.40 (0.03–1.00)

Segm.

ErrSAX

660

0.01

[−12.8;12.8]£

34.3

±18.1

0.83 (0.77–0.88)

EccSAX

660

0.90*

[−5.0;6.8]

29.3

±8.3

0.83 (0.77–0.89)

EllLAX

140

1.42*

[−5.7;8.5]£

45.6

±10.0

0.51 (0.36–0.78)

  1. # - Sample Size; LOA Limits of agreement; CV Coefficient of Variance (%); CR Coefficient of repeatability; ICC Intraclass correlation coefficient; CI Coefficient Interval
  2. *p < 0.05, two tailed paired t-test against zero
  3. $ p < 0.05, two tailed F-test between Expert versus Skilled observer variability
  4. £ p < 0.05, two tailed F-test between Expert versus Beginner variability