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Table 4 Inter-study variability in the healthy volunteer

From: Cardiovascular magnetic resonance myocardial feature tracking using a non-rigid, elastic image registration algorithm: assessment of variability in a real-life clinical setting

Inter-study # Bias LOA CV CR ICC (95% CI)
Expert Global ErrSAX 120 1.34* [−7.1;9.8]£ 22.0 ±12.0 0.87 (0.74–0.95)
EccSAX 120 0.26 [−2.3;2.9] 13.5 ±3.7 0.90 (0.79–0.97)
EllLAX 20 −1.79* [−3.3;-0.3]£ 9.6 ±2.1 0.52 (0.10–1.00)
Segm. ErrSAX 660 −0.23 [−11.8;11.4] 30.7 ±16.4 0.86 (0.80–0.91)
EccSAX 660 1.02* [−4.3;6.3] 26.8 ±7.5 0.84 (0.78–0.89)
EllLAX 140 0.66* [4.8;6.1]£ 33.4 ±7.7 0.60 (0.41–0.81)
Skilled Observer Global ErrSAX 120 1.53* [−7.2;10.3] 22.8 ±12.4 0.86 (0.72–0.95)
EccSAX 120 0.08 [−2.8;3.0] 15.5 ±4.1 0.88 (0.77–0.96)
EllLAX 20 −1.56* [−3.2;0.1] 10.4 ±2.3 0.50 (0.08–1.00)
Segm. ErrSAX 660 −0.29 [−11.0;10.4]$ 28.3 ±15.1 0.87 (0.81–0.91)
EccSAX 660 0.95* [−4.0;5.9] 25.7 ±7.0 0.87 (0.83–0.91)
EllLAX 140 0.86* [−4.2;6.0] 32.2 ±7.3 0.60 (0.40–0.80)
Beginner Global ErrSAX 120 0.83 [−8.5;10.1]£ 24.6 ±13.1 0.84 (0.69–0.94)
EccSAX 120 0.13 [−3.0;3.3] 16.0 ±4.5 0.88 (0.76–0.96)
EllLAX 20 −2.06* [−4.2;0.1]£ 13.7 ±3.1 0.40 (0.03–1.00)
Segm. ErrSAX 660 0.01 [−12.8;12.8]£ 34.3 ±18.1 0.83 (0.77–0.88)
EccSAX 660 0.90* [−5.0;6.8] 29.3 ±8.3 0.83 (0.77–0.89)
EllLAX 140 1.42* [−5.7;8.5]£ 45.6 ±10.0 0.51 (0.36–0.78)
  1. # - Sample Size; LOA Limits of agreement; CV Coefficient of Variance (%); CR Coefficient of repeatability; ICC Intraclass correlation coefficient; CI Coefficient Interval
  2. *p < 0.05, two tailed paired t-test against zero
  3. $ p < 0.05, two tailed F-test between Expert versus Skilled observer variability
  4. £ p < 0.05, two tailed F-test between Expert versus Beginner variability