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Table 3 Predictors of adverse clinical outcome. Clinical presentation, EMB results and CMR parameters related to an adverse clinical outcome

From: Abnormal T2 mapping cardiovascular magnetic resonance correlates with adverse clinical outcome in patients with suspected acute myocarditis

  Recovery Combined Endpoint p-value OR (CI 95%)
(n = 34) (n = 11)
Age (years) 32.8 ± 14.7 48.4 ± 13.2 0.05  
male 24 (71) 5 (45) 0.16 2.9 (0.86–1.25)
Clinical Presentation     
 Chest Pain 21 (62) 5 (45) 0.49 0.5 (0.13–1.83)
 Palpitations 3 (9) 4 (36) 0.05 5.9 (1.27–26.33)
 Fatigue 25 (74) 8 (73) 0.99 0.9(0.24–3.39)
 Dyspnoea (NYHA Class)     
   III 8 (24) 6 (55) 0.07 3.9 (1.04–16.96)
   IV 4 (12) 2 (18) 0.62 1.7 (0.28–8.62)
Blood Testing
 Troponin (ng/ml) 363 ± 8135 103 ± 143 0.19  
 BNP (pg/ml) 4046 ± 8135 3636 ± 2497 0.91  
EMB Results     
 Imflammation on EMB 15 (54) 5 (50) 0.99 1.0 (0.29–4.21)
 Presence of virus genome 13 (52) 8 (73) 0.29 2.5 (0.57–9.91)
CMR Parameters
 LVEF (%) 44 ± 13 33 ± 14 0.02  
 LVEF <30% 7 (21) 7 (64) 0.02 6.8 (1.56–24.12)
 Presence of LGE 26 (76) 10 (91) 0.25 4.2 (0.62–49.34)
 T2 Ratio >1.9 14 (41) 5 (45) 0.99 1.2 (0.31–4.09)
 Global T2 Time (ms) 66.8 ± 4.9 71.8 ± 5.7 0.01  
 Global T2 Time, >2SD 12 (35) 8 (73) 0.04 4.9 (1.1–18.9)
 Global T2 Time, >4SD 4 (12) 5 (45) 0.02 6.3 (1.2–24.9)
 Fraction with T2 Time >80 ms (%) 15.1 ± 8.7 27.5 ± 14.9 0.03  
 Fraction with T2 Time >80 ms, >2SD 23 (68) 10 (91) 0.24 4.7 (0.7–56.2)
 Fraction with T2 Time >80 ms, >4SD 12 (35) 8 (73) 0.04 4.9 (1.1–18.9)
  1. Abbreviations: Fraction >80 ms Percentage of myocardial fraction with T2 time >80 ms, BNP Brain Natriuretic Peptide, EMB Endomyocardial Biopsy, LVEF Left ventricular ejection fraction, LGE presence of Late Gadolinium Enhancement, T2w Imaging increased T2 ratio >1.9 (T2 weighted Imaging)