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Table 3 Predictors of adverse clinical outcome. Clinical presentation, EMB results and CMR parameters related to an adverse clinical outcome

From: Abnormal T2 mapping cardiovascular magnetic resonance correlates with adverse clinical outcome in patients with suspected acute myocarditis

 

Recovery

Combined Endpoint

p-value

OR (CI 95%)

(n = 34)

(n = 11)

Age (years)

32.8 ± 14.7

48.4 ± 13.2

0.05

 

male

24 (71)

5 (45)

0.16

2.9 (0.86–1.25)

Clinical Presentation

    

 Chest Pain

21 (62)

5 (45)

0.49

0.5 (0.13–1.83)

 Palpitations

3 (9)

4 (36)

0.05

5.9 (1.27–26.33)

 Fatigue

25 (74)

8 (73)

0.99

0.9(0.24–3.39)

 Dyspnoea (NYHA Class)

    

   III

8 (24)

6 (55)

0.07

3.9 (1.04–16.96)

   IV

4 (12)

2 (18)

0.62

1.7 (0.28–8.62)

Blood Testing

 Troponin (ng/ml)

363 ± 8135

103 ± 143

0.19

 

 BNP (pg/ml)

4046 ± 8135

3636 ± 2497

0.91

 

EMB Results

    

 Imflammation on EMB

15 (54)

5 (50)

0.99

1.0 (0.29–4.21)

 Presence of virus genome

13 (52)

8 (73)

0.29

2.5 (0.57–9.91)

CMR Parameters

 LVEF (%)

44 ± 13

33 ± 14

0.02

 

 LVEF <30%

7 (21)

7 (64)

0.02

6.8 (1.56–24.12)

 Presence of LGE

26 (76)

10 (91)

0.25

4.2 (0.62–49.34)

 T2 Ratio >1.9

14 (41)

5 (45)

0.99

1.2 (0.31–4.09)

 Global T2 Time (ms)

66.8 ± 4.9

71.8 ± 5.7

0.01

 

 Global T2 Time, >2SD

12 (35)

8 (73)

0.04

4.9 (1.1–18.9)

 Global T2 Time, >4SD

4 (12)

5 (45)

0.02

6.3 (1.2–24.9)

 Fraction with T2 Time >80 ms (%)

15.1 ± 8.7

27.5 ± 14.9

0.03

 

 Fraction with T2 Time >80 ms, >2SD

23 (68)

10 (91)

0.24

4.7 (0.7–56.2)

 Fraction with T2 Time >80 ms, >4SD

12 (35)

8 (73)

0.04

4.9 (1.1–18.9)

  1. Abbreviations: Fraction >80 ms Percentage of myocardial fraction with T2 time >80 ms, BNP Brain Natriuretic Peptide, EMB Endomyocardial Biopsy, LVEF Left ventricular ejection fraction, LGE presence of Late Gadolinium Enhancement, T2w Imaging increased T2 ratio >1.9 (T2 weighted Imaging)