Table 3 Hemodynamic and CMR findings in response to inhaled 100% O2 and 40 ppm NO in patients with and without pulmonary hypertension
Baseline | 100% O2 + 40 ppm NO | p value | |
|---|---|---|---|
Normal pulmonary pressures (n = 30) | |||
Mean PA pressure (mmHg) | 18 ± 4 | 16 ± 5 | 0.01* |
Mean PAWP (mmHg) | 9 ± 3 | 10 ± 3 | 0.008* |
Cardiac index (L/min/m2) by CMR flow | 2.6 ± 0.1 | 2.5 ± 0.1 | 0.65 |
RV end diastolic volume (mL) | 74 ± 24 | 73 ± 24 | 0.41 |
RV end systolic volume (mL) | 27 ± 12 | 25 ± 13 | 0.22 |
RV stroke volume (mL) | 47 ± 15 | 47 ± 15 | 0.61 |
RV ejection fraction (%) | 64 ± 9 | 66 ± 11 | 0.03* |
LV end diastolic volume (mL) | 75 ± 20 | 76 ± 20 | 0.11 |
LV end systolic volume (mL) | 32 ± 18 | 33 ± 18 | 0.10 |
LV stroke volume (mL) | 43 ± 9 | 43 ± 9 | 0.93 |
LV ejection fraction (%) | 60 ± 11 | 59 ± 11 | 0.18 |
Pulmonary hypertension (n = 28) | |||
Mean PA pressure (mmHg) | 39 ± 12 | 34 ± 12 | <0.001* |
Mean PAWP (mmHg) | 16 ± 6 | 16 ± 8 | 0.75 |
Cardiac index (L/min/m2) by CMR flow | 3.1 ± 0.3 | 3.0 ± 0.2 | 0.44 |
RV end diastolic volume (mL) | 120 ± 73 | 112 ± 74 | 0.01* |
RV end systolic volume (mL) | 57 ± 35 | 52 ± 40 | 0.06 |
RV stroke volume (mL) | 64 ± 41 | 61 ± 37 | 0.22 |
RV ejection fraction (%) | 54 ± 12 | 56 ± 11 | 0.17 |
LV end diastolic volume (mL) | 89 ± 33 | 92 ± 34 | 0.045* |
LV end systolic volume (mL) | 39 ± 21 | 42 ± 25 | 0.07 |
LV stroke volume (mL) | 50 ± 14 | 50 ± 10 | 0.94 |
LV ejection fraction (%) | 59 ± 10 | 58 ± 9 | 0.22 |