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Table 4 Hemodynamic and CMR findings in response to inhaled 100% O2 and 40 ppm NO in patients with and without a 20% reduction in PVRi

From: CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients

 

Baseline

100% O2 + 40 ppm NO

p value

Positive vasodilatory response (n = 29)

 Mean PA pressure (mmHg)

26 ± 12

22 ± 10

<0.001*

 Mean PAWP (mmHg)

13 ± 6

14 ± 7

0.11

 Cardiac index (L/min/m2) by CMR flow

3.0 ± 0.2

2.9 ± 0.2

0.06

 PVRi (WU.m2) by CMR flow

4.2 ± 3.2

2.6 ± 2.2

<0.001*

 RV end diastolic volume (mL)

96 ± 63

91 ± 63

0.014*

 RV end systolic volume (mL)

39 ± 32

36 ± 35

0.12

 RV stroke volume (mL)

57 ± 34

55 ± 32

0.14

 RV ejection fraction (%)

62 ± 11

63 ± 12

0.19

Negative vasodilatory response (n = 15)

 Mean PA pressure (mmHg)

25 ± 12

24 ± 11

0.08

 Mean PAWP (mmHg)

11 ± 5

11 ± 4

0.65

 Cardiac index (L/min/m2) by CMR flow

2.7 ± 0.8

2.7 ± 0.8

0.98

 PVRi (WU.m2) by CMR flow

4.9 ± 3.8

4.9 ± 3.4

0.97

 RV end diastolic volume (mL)

79 ± 23

81 ± 26

0.44

 RV end systolic volume (mL)

35 ± 15

33 ± 17

0.33

 RV stroke volume (mL)

45 ± 14

48 ± 12

0.014*

 RV ejection fraction (%)

58 ± 11

62 ± 13

0.008*

  1. Categorical variables are presented as percentages and continuous variables as mean ± standard deviation. Cardiac index and PVRi were derived from CMR flow. PA pulmonary artery, PAWP pulmonary artery wedge pressure, PVRi pulmonary vascular resistance index, RV right ventricle