Fig. 1

The natural history of myocardial function in an adult human population. LVEDV statistically significantly decreased over 10 years for each age category a and LV mass increased in Men b and M/V ratio increased c despite LV mass did not progressively increase b and d. Although SV progressively falls, LVEF maintains due to progressive decline in LV volumes e. Aging is associated with the development of a concentric remodeling pattern secondary to a progressive decline in LV volume f. LV = left ventricular; LVEF = left ventricular ejection fraction; LVEDV = Left ventricular end diastolic volume; LVESV = Left ventricular end systolic volume; M/V = mass-to-volume ratio Figures prepared based on data from Eng et al. [8], and Cheng et al. [5]