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Table 1 Baseline characteristics of STEMI patients with a CTO, stratified for the randomization outcome, in total group and in patients with serial CMR

From: Improved recovery of regional left ventricular function after PCI of chronic total occlusion in STEMI patients: a cardiovascular magnetic resonance study of the randomized controlled EXPLORE trial

  Serial CMR (n = 180) Total (n = 302)
CTO-PCI
(n = 80)
No CTO-PCI (n = 100) CTO-PCI
(n = 148)
No CTO-PCI
(n = 154)
P-value*
Age (years, mean, SD) 60(10) 60(10) 60(10) 60(10) 0.81
Male gender (%) 73(91) 84(84) 131(89) 126(82) 0.25
Diabetes (%) 13(16) 14(14) 22(15) 25(16) 0.75
Hypertension (%) 30(38) 48(48) 59(40) 69(45) 0.72
Family history of CAD (%) 32(40) 38(38) 66(45) 64(42) 0.10
Hypercholesterolaemia (%) 27(34) 33(33) 51(35) 52(34) 0.81
Current smoker (%) 40(50) 52(52) 77(52) 76(49) 0.97
Previous MI (%) 9(11) 17(17) 19(13) 24(16) 1.0
Previous PCI (%) 5(6) 13(13) 9(6) 16(10) 0.21
Previous stroke (%) 2(3) 3(3) 5(3) 6(4) 0.36
Primary PCI
 Infarct related artery 0.77
  Right coronary artery (%) 26(32) 31(31) 46(31) 47(31)  
  Left circumflex artery (%) 15(19) 30(30) 30(20) 43(28)  
  Left anterior descending artery/LM (%) 39(49) 39(39) 72(49) 64(42)  
  Three vessel disease (%) 34(43) 42(42) 62(42) 67(44) 0.91
  MI SYNTAX score I (pre-PCI) 30(8) 29(10) 29(8) 29(10) 0.57
  MI SYNTAX score II (wiring/balloon/aspiration) 28(8) 26(10) 27(8) 27(10) 0.62
 Infarct size
  Peak CK-MB (median, IQR) 133(38–198) 87(39–199) 130(39–272) 111(43–256) 0.14
  Peak Troponin T(median, IQR) 3.1(1.3–7.8) 2.9(0.9–5.6) 3.1(1.1–7.8) 3.3(0.9–6.0) 0.23
  LVEF before randomization a 41(12) 42(12) 41(11) 42(12) 0.97
CTO characteristics
 Patients with multiple CTOs b 11(14) 13(13) 13(9) 22(14) 0.28
 CTO related artery 0.61
  Right coronary artery 32(40) 54(54) 46(43) 78(51)  
  Left circumflex artery 23(29) 24(24) 48(32) 37(24)  
  Left anterior descending artery 25(31) 22(22) 36(24) 39(25)  
 CTO Collaterals Rentrop Grade 2–3 48(60) 53(53) 80(54) 82(53) 0.30
 Total J-CTO score (mean, SD) 2.0(1.1) 2.2(1.1) 2.1(1.1) 2.3(1.1) 0.07
  Previously failed lesion 1(1) 4(4) 2(1) 4(3) 0.41
  Blunt stump 17(21) 27(27) 33(22) 45(29) 0.51
  Bending 50(63) 68(68) 98(66) 108(70) 0.26
  Calcification 58(73) 81(81) 115(78) 132(86) 0.02
  Occlusion length ≥ 20 mm 30(38) 43(43) 60(40) 68(44) 0.48
  1. Data are number of patients (%), mean (SD) or median (IQR)
  2. PCI percutaneous coronary intervention, CK-MB creatine kinase-MB isoenzyme, CTO chronic total occlusion, J-CTO Multicenter CTO registry of Japan, CMR cardiovascular magnetic resonance
  3. *p-value for patients with serial CMR versus patients without serial CMR
  4. aImaging modality is CMR only; data available in 201 patients
  5. bFor patients with multiple CTOs, the CTO supplying the largest amount of myocardium was defined as the main CTO