Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics

Table 3 The discriminatory value of various strain and LGE parameters to differentiate Cardiac Amyloidosis from Fabry’s Disease or Hypertrophic Cardiomyopathy

Ratio	AUC (95% CI)	Discrimination threshold	Sensitivity	specificity
RSSR	0.66 (0.55–0.76)	>1.05	43.0%	82.0%
LGE ratio alone	0.62 (0.51–0.72)	≤0.58	97.9%	44.7%
RSSR/Relative LGE ratio	0.67 (0.55–0.77)	>1.20	97.8%	44.4%
Basal strain/basal LGE^a	0.94 (0.88–0.98)	≤0.77	91.1%	84.2%
Mid strain/mid LGE^a	0.90 (0.81–0.96)	≤1.64	93.3%	79.0%
Apical strain/apical LGE^a	0.80 (0.69–0.88)	≤2.80	86.7%	70.3%

^aCalculated as the absolute value of the longitudinal strain for that ventricular level (i.e. base, mid, or apical) divided by the LGE percentage for that same level

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