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Table 3 Intraclass correlation coefficients (ICCs) for the three models

From: Synthetic hematocrit derived from the longitudinal relaxation of blood can lead to clinically significant errors in measurement of extracellular volume fraction in pediatric and young adult patients

  Published Model Static Hct (Partition Coefficient) Local Model
  ICC 95% CI ICC 95% CI ICC 95% CI
Hctall (n = 163) 0.40 [0.27, 0.52] --- --- 0.28 [0.13, 0.42]
Hctsame day (n = 146) 0.43 [0.29, 0.56] --- --- 0.32 [0.17, 0.46]
Hctcontrol (n = 18) 0.54 [0.12, 0.80] --- --- 0.25 [−0.23, 0.63]
HctDMD (n = 86) 0.38 [0.18. 0.54] --- --- 0.27 [0.07, 0.46]
Hctcongenital (n = 24) 0.33 [−0.07, 0.64] --- --- 0.31 [−0.10, 0.63]
ECVall mid-septum (n = 159) 0.85 [0.80, 0.89] 0.89 [0.85, 0.92] 0.91 [0.88, 0.93]
ECVsame day mid-septum (n = 142) 0.83 [0.77, 0.88] 0.88 [0.84, 0.91] 0.90 [0.87, 0.93]
ECVcontrol mid-septum (n = 18) 0.94 [0.85, 0.98] 0.88 [0.69, 0.95] 0.92 [0.79, 0.97]
ECVDMD mid-septum (n = 86) 0.86 [0.81, 0.91] 0.92 [0.87, 0.95] 0.93 [0.89, 0.95]
ECVcongenital mid-septum (n = 24) 0.82 [0.63, 0.92] 0.86 [0.71, 0.94] 0.89 [0.76, 0.95]
ECVall mid-free wall (n = 159) 0.93 [0.91, 0.95] 0.92 [0.89, 0.94] 0.93 [0.91, 0.95]
ECVsame day mid-free wall (n = 142) 0.90 [0.87, 0.93] 0.92 [0.89, 0.94] 0.94 [0.92, 0.96]
ECVcontrol mid-free wall (n = 18) 0.97 [0.93, 0.99] 0.94 [0.84, 0.98] 0.96 [0.90, 0.99]
ECVDMD mid-free wall (n = 86) 0.89 [0.84, 0.93] 0.94 [0.90, 0.96] 0.94 [0.92, 0.96]
ECVcongenital mid-free wall (n = 24) 0.83 [0.64, 0.92] 0.85 [0.68, 0.93] 0.88 [0.73, 0.94]
  1. ICCs for Hct in the entire cohort (Hctall) as well as subsets of controls, DMD patients, and patients with congenital heart disease were all higher for the published model compared to the local model, though the confidence intervals suggest the differences may not be significant. There was no significant difference in ICCs between these subgroups for either model. The ICCs for ECVmid-septum and ECVmid-free wall for all three models were comparably strong, with the local model marginally better for the overall cohort. ICCs were not significantly different when calculated with or without same day Hct sub-group included