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Table 4 Diagnostic performance of different CMR parameters for diagnosing suspected acute myocarditis

From: A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking

Parameter AUCa Sensitivity [%] Specificity [%] PPVb [%] NPVc [%] Accuracy [%]
Lake Louise criteria
 T2-Ratio (≥1.9) 0.58 40 77 87 25 48
 Visual edema 0.72 43 100 100 31 55
 EGErd 0.74 48 100 100 33 58
 LGEe 0.76 52 100 100 35 62
Strain parameters
 LVf longitudinal strain 0.68 73 59 88 36 70
 LV longitudinal SRg 0.66 60 71 89 31 62
 LV circumferential strain 0.70 52 88 95 32 60
T2 parameters
 Mean T2 0.75 69 82 94 40 71
 MaxT2 0.79 87 82 95 61 86
 Mean SD 0.70 72 71 91 39 71
 MadSD 0.82 84 77 93 54 82
Multiparametric models without gadolinium
 madSD + LV longitudinal strain 0.84 93 71 93 71 88
 madSD + LV circumferential strain 0.84 93 82 95 74 91
 madSD ≥1.8 ms + LV circumferential strain ≥ −25% 0.84 90 77 95 67 88
Multiparametric models with gadolinium       
 LLCh 0.79 58 100 100 38 67
 madSD + LV longitudinal strain + LGE 0.94 99 77 94 93 94
 madSD + LV circumferential strain + LGE 0.93 97 82 96 88 94
 madSD ≥1.8 ms + LV circumferential strain ≥ −25%
 + LGE pos.
0.94 97 77 96 88 94
  1. a AUC area under the curve, b PPV positive predictive value, c NPV negative predictive value, d EGEr Early Gadolinium Enhancement ratio, e LGE Late Gadolinium Enhancement, f LV left ventricle, gSR strain rate, h LLC Lake Louise criteria