Table 4 Pooled diagnostic accuracy of semi-quantitative and quantitative CMR perfusion analysis on segmental, territory, and per patient basis (bold) and subgroup analysis of anatomical/functional reference standard or semi-quantitative/quantitative analysis (unbold)
| Â | No. Studies | No. S/T/P | Sensitivity | Q-statistics p-valuea | I2b | Specificity | Q-statistics p-valuea | I2b | PLR | NLR | DOR | AUC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Per Segment | 4 | 3838 | 0.88 (0.82–0.93) | 0.00 | 82.04 | 0.72 (0.56–0.84) | 0.00 | 96.23 | 3.1 (1.0–5.10) | 0.16 (0.10–0.26) | 19 (9–40) | 0.90 (0.870.92) |
Per territory | 12 | 1058 | 0.82 (0.77–0.86) | 0.49 | 0.00 | 0.83 (0.74–0.90) | 0.00 | 90.68 | 5.0 (3.1–7.9) | 0.22 (0.17–0.29) | 23 (12–44) | 0.84 (0.81–0.87) |
Anatomical reference | 5 | 370 | 0.85 (0.78–0.90) | 0.49 | 0.00 | 0.83 (0.72–0.91) | 0.00 | 78.11 | 5.1 (2.9–9.2) | 0.18 (0.12–0.27) | 28 (13–63) | 0.86 (0.83–0.89) |
Functional reference | 7 | 688 | 0.77 (0.63–0.86) | 0.00 | 86.70 | 0.85 (0.73–0.92) | 0.00 | 93.19 | 5.1 (2.5–10.3) | 0.28 (0.16–0.48) | 18 (6–59) | 0.88 (0.84–0.90) |
Semi-quantitative | 6 | 343 | 0.77 (0.60–0.88) | 0.00 | 86.96 | 0.84 (0.76–0.89) | 0.30 | 17.10 | 4.7 (2.9–7.8) | 0.28 (0.15–0.53) | 17 (6–50) | 0.87 (0.84–0.90) |
Quantitative | 6 | 729 | 0.77 (0.62–0.87) | 0.00 | 89.39 | 0.86(0.72–0.94) | 0.00 | 94.92 | 5.5 (2.4–12.6) | 0.27 (0.14–0.49) | 21 (6–8) | 0.88(0.85–0.91) |
Per patient | 10 | 566 | 0.83 (0.75–0.88) | 0.01 | 60.71 | 0.76 (0.65–0.85) | 0.00 | 66.27 | 3.5 (2.2–5.5) | 0.23 (0.14–0.36) | 15 (6–36) | 0.87 (0.84–0.90) |