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Table 3 Univariable and multivariable Cox’s proportional hazard models for the association with appropriate ICD therapy

From: Left ventricular geometry predicts ventricular tachyarrhythmia in patients with left ventricular systolic dysfunction: a comprehensive cardiovascular magnetic resonance study

 

Univariate analysis

Multivariate analysis model 1

Multivariate analysis model 2

Characteristics

HR

95% CI

P Value

HR

95% CI

P Value

HR

95% CI

P Value

Age,yrs

1.01

0.96–1.06

0.63

1.02

0.97–1.08

0.41

1.02

0.97–1.08

0.43

Male

3.22

0.72–14.42

0.13

      

Biventricular ICD

0.49

0.15–1.58

0.23

      

Ischemic cardiomyopathy

2.42

0.83–7.10

0.11

      

Hypertension

2.16

0.49–9.59

0.31

      

Diabetes mellitus

2.04

0.72–5.78

0.18

      

Dyslipidemia

0.77

0.27–2.24

0.63

      

Serum creatinine, per 0.1 increase

1.19

0.97–1.46

0.10

      

QRS duration

1.00

0.99–1.02

0.72

      

NYHA ≥ III

2.65

0.75–9.42

0.13

      

CMR parameters

 Sphericity index, per 0.01 increase

1.09

1.02–1.16

0.007

1.09

1.02–1.16

0.007

   

 Sphericity index > 0.57

4.49

1.53–13.21

0.006

   

4.49

1.53–13.21

0.006

 RWT, per 0.01 increase

1.01

0.94–1.10

0.75

      

 LV EDVI

1.01

1.00–1.02

0.18

      

 LV ESV

1.01

1.00–1.01

0.039

      

 LV EF, per 1% decrement

1.09

1.03–1.15

0.005

1.07

0.99–1.13

0.08

1.07

0.99–1.13

0.08

 LV mass index

1.01

1.00–1.02

0.039

      

 LV mass/LV EDV

4.56

0.11–198.25

0.43

      

 LV LGE

2.45

0.78–7.72

0.13

      

 LV LGE2SD

1.01

1.00–1.03

0.14

      

 LV heterogeneous LGE(2-4SD)

1.07

1.02–1.12

0.01

      

 RV EDVI

1.01

0.98–1.03

0.58

      

 RV ESV

1.01

1.00–1.02

0.10

      

 RV EF, per 1% decrement

1.04

1.00–1.08

0.054

      

 RV EF < 40%

3.92

1.42–10.85

0.009

      
  1. Variables given are mean ± SD or N (%) or median (interquartile range)
  2. Abbreviation as in Tables 1 and 2
  3. Model 1 included sphericity index, LVEF and age. Model 2 included sphericity index > 0.57, LVEF and age
  4. HR (hazard ratio) refers to the ratio of hazards of the presence of the characteristic to the reference (absence), or to the change of 1 unit (continuous variable)