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Table 1 Baseline Characteristics. Patients with primary combined endpoint versus transplant-free survivors (n = 68)

From: Regional differences in prognostic value of cardiac valve plane displacement in systemic light-chain amyloidosis

Parameter Transplant-free Survivors
(n = 24)
Heart transplantation or death
(n = 44)
p
Age (yrs) 57 ± 8 59 ± 11 n.s.
Male (n)a 13 (54%) 27 (61%) n.s.
BMI (kg/m2) 25 (23-27) 25 (23-27) n.s.
Heart rate (bpm) 78 ± 13 80 ± 14 n.s.
NYHA class 2 (2-3) 3 (2-3) 0.03
Karnofsky Index 85 ± 6 76 ± 10 0.0001
Laboratory data
 MDRD (mL/min/1.73m2) 81 ± 17 83 ± 14 n.s.
 NT-proBNP (pg/mL) 1177 (528-3249) 3243 (1157-7505) 0.01
 cTNT ULN (n)a 8 (38%) 18 (41%) n.s.
 FLC difference (mg/dL) 1,1130 (435-5435) 3351 (975-8971) n.s.
CMR parameters
 AAPSE (mm) 8.8 (6.9-10.4) 6.1 (4.6-9.4) 0.02
 MAPSE anterior (mm) 8.1 (5.3-10.0) 6.2 (4.1-8.6) n.s.
 MAPSE anterolateral (mm) 10.5 (8.1-13.4) 7.3 (5.4-11.7) 0.03
 MAPSE inferolateral (mm) 9.3 (6.3-12.1) 7.6 (5.2-12.2) n.s.
 MAPSE inferior (mm) 9.2 (7.4-11.1) 8.0 (5.0-11.7) n.s.
 MAPSE inferoseptal (mm) 7.6 (6.1-10.4) 7.1 (4.5-10.8) n.s.
 TAPSE (mm) 18.0 (10.0-22.4) 14.1 (9.0-19.7) n.s.
 GLS (%) −14.8 ± 5.1 −13.2 ± 5.2 n.s.
 LSbasal (%) −12.3 ± 6.1 −11.4 ± 8.5 n.s.
 LSmid (%) −16.4 ± 5.2 −14.7 ± 5.5 n.s.
 LSapical (%) −17.6 ± 5.9 −16.2 ± 6.6 n.s.
 Ejection Fraction (%) 62 ± 10 55 ± 13 0.03
 Septal wall (mm) 14 ± 5 13 ± 3 n.s.
 Lateral wall (mm) 10 ± 4 10 ± 4 n.s.
 Relative LV Mass (g/m2) 75 ± 21 73 ± 35 n.s.
 LA (mm) 39 ± 7 42 ± 7 n.s.
 Relative LGE (%) 16.5 (10.0-35.7) 25.0 (18.1-30.4) n.s.
 Qualitative LGE (n) 2 (2-3) 2 (2-3) n.s.
  1. Normal distributed variables are presented as mean ± SD, non-parametric distributions are shown as Median (1st quartile-3rd quartile). adichotomous variable
  2. BMI body mass index, MDRD glomerular filtration rate calculated with the formula of “Modification of Diet in Renal Disease”, NT-proBNP N-terminal prohormone of brain natriuretic peptide, cTNT ULN cardiac troponin T upper limit of normal, FLC free light chain difference, AAPSE anterior aortic plane systolic excursion, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, GLS global longitudinal strain, LS basal mean longitudinal strain of basal segments 1-6, LS mid mean longitudinal strain of midventricular segments 7-12, LS apical mean longitudinal strain of apical segments 13-16, LA left atrium, relative LGE proportion of late gadolinium enhancement quantified by 5SD method, qualitative LGE Late Gadolinium Enhancement graduated in (1) none, (2) subendocardial or (3) transmural involvement
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