Regional differences in prognostic value of cardiac valve plane displacement in systemic light-chain amyloidosis

Table 2 Univariate Cox-regression for overall survival or heart transplantation (n = 68)

Variable	X²	HR	95% CI	p
NYHA class	7.5	1.75	1.15 to 2.68	0.001
Karnofsky Index	21.3	0.91	0.88 to 0.95	0.0001
CMR parameters
AAPSE (mm)	15.6	0.10	0.03 to 0.34	0.0002
MAPSE anterior (mm)	8.1	0.19	0.06 to 0.60	0.004
MAPSE anterolateral (mm)	11.7	0.23	0.10 to 0.56	0.001
MAPSE inferolateral (mm)	6.2	0.36	0.16 to 0.83	0.02
MAPSE inferior (mm)	9.0	0.26	0.10 to 0.63	0.003
MAPSE inferoseptal (mm)	7.7	0.26	0.10 to 0.68	0.01
TAPSE (mm)	6.7	0.94	0.90 to 0.99	0.01
GLS (%)	11.7	1.12	1.05 to 1.19	0.0006
LS_basal (%)	8.3	1.08	1.02 to 1.13	0.006
LS_mid (%)	12.8	1.13	1.06 to 1.21	0.0005
LS_apical (%)	6.9	1.07	1.02 to 1.12	0.005
Ejection Fraction (%)	11.6	0.95	0.93 to 0.98	0.0007
Septal wall (mm)	0.7	1.03	0.96 to 1.11	n.s.
Relative LV Mass (g/m²)	1.8	1.01	0.99 to 1.02	n.s.
LA dilation ^a	0.02	1.05	0.55 to 1.97	n.s.
Relative LGE (%)	4.4	1.02	1.00 to 1.04	0.03
Qualitative LGE (n)	6.8	1.50	1.09 to 2.06	0.009
Laboratory data
cTNT ULN ^a	5.3	1.94	1.09 to 3.45	0.02
log NT-proBNP (pg/mL)	13.0	1.52	1.20 to 1.94	0.0006
MDRD (mL/min/1.73m²)	0.2	1.00	0.99 to 1.01	n.s.
log FLC difference (mg/dL)	6.3	1.71	1.10 to 2.65	0.02

X ² chi square, HR hazard ratio, CI confidence interval, ^adichotomous variable
AAPSE anterior aortic plane systolic excursion, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, GLS global longitudinal strain, LS _basal mean longitudinal strain of basal segments 1-6, LS _mid mean longitudinal strain of midventricular segments 7-12, LS _apical mean longitudinal strain of apical segments 13-16, LA left atrium, relative LGE proportion of late gadolinium enhancement quantified by 5SD method, qualitative LGE late gadolinium enhancement graduated in (1) none, (2) subendocardial or (3) transmural involvement, cTNT ULN cardiac troponin T upper limit of normal, NT-proBNP N-terminal prohormone of brain natriuretic peptide, MDRD glomerular filtration rate calculated with the formula of “Modification of Diet in Renal Disease”, FLC free light chain difference

ISSN: 1532-429X