Table 1 Cardiovascular MRI assessment

 Number of animals

7

7

 Weight (kg)

21.9 (16–29)

23.7 (20–27)

NS

 Body surface area (m²)

0.56 (0.46–0.67)

0.58 (0.52–0.63)

NS

 Heart rate (bpm)

78 (57–106)

72 (57–116)

NS

 EDV (ml/m²)

66 (57–81)

71 (57–82)

NS

 ESV (ml/m²)

33 (22–38)

28 (23–46)

NS

 Stroke volume (ml/m²)

36 (28–49)

38 (26–50)

NS

 Ejection fraction (%)

53 (48–60)

57 (45–65)

NS

 Cardiac index (l/min/m²)

2.5 (1.5–4.4)

2.6 (2.2–3.3)

NS

 LV SL/AP ratio, systole

1.04 (0.89–1.15)

1.05 (1.03–1.13)

NS

 LV SL/AP ratio, diastole

0.98 (0.89–1.16)

0.98 (0.91–1.03)

NS

 In-vivo wall thickness, systole (mm)

10.7 (10.3–12.6)

11.6 (9.6–13.4)

NS

 In-vivo wall thickness, diastole (mm)

7.4 (6.9–8)

7.4 (6.6–8.7)

NS

 Ex-vivo wall thickness, diastole (mm)

6.7 (5.1–8.3)

6.6 (5.8–7.5)

NS

 RVEDV (ml/m²)

86 (70–116)

53 (48–76)

0.006

 RVESV (ml/m²)

40 (36–54)

27 (20–40)

0.01

 RV ejection fraction (%)

48 (41–73)

50 (38–55)

NS

 RV regurgitation volume (ml/m²)

12.6 (4.2–19.6)

0.34 (0.12–0.62)

0.002

 RV regurgitation fraction (%)

39 (17–44)

1.5 (0.3–2.9)

0.002

 Ventricular length, systole (mm)

63 (58–77)

64 (53–70)

NS

 Ventricular length, diastole (mm)

75 (68–80)

75 (68–89)

NS

 Septum-lateral distance, systole (mm)

21 (16–28)

18 (14–24)

NS

 Septum-lateral distance, diastole (mm)

29 (27–32)

26 (19–29)

0.01

 Ex-vivo wall thickness, diastole (mm)

3.7 (3.2–4.2)

3.4 (2.6–4.2)

NS