Fig. 3

Changes in ejection fraction following vasodilator administration: Observed changes in left ventricular (LV) ejection fraction (LVEF) from baseline values following administration of adenosine (dashed line) and regadenoson (solid line) are shown in (a) and changes in right ventricular (RV) EF from baseline values are shown in (b). The Post-vasodilator time point represents short-axis cine data sets acquired immediately following vasodilator (VD) administration. P-values shown represent differences in the magnitude of EF change at each time point between adenosine and regadenoson. LVEF returned to baseline following adenosine infusion by the 10 min mark (p = 0.84) whereas LVEF following regadenoson remained elevated compared with baseline at the 15 min mark (p = 0.0015). Regarding RVEF (b), maximal impact of regadenoson occurred later than adenosine with adenosine returning to baseline by 15 min (p = 0.29). RVEF continued to be elevated at the 15 min mark following regadenoson administration (p = 0.016)