Skip to main content

Table 1 Baseline clinical and imaging characteristics

From: Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis

  

Aortic stenosis (N = 104)

AS + CA (N = 9)

P Value

Clinical

Age (years)

70 ± 14

88 ± 6

< 0.001

Male Gender

58 (56%)

8 (89%)

0.057

Hypertension

76 (73.1%)

7 (77.8%)

0.866

Diabetes

36 (34.6%)

3 (33.3%)

0.890

Creatinine (mg/dl)

1.26 ± 0.94

1.54 ± 0.45

0.380

Prior Revascularization (PCI or CABG)

33 (31.7%)

3 (33.3%)

0.968

NYHA Class ≥ III at baseline

57 (55%)

7 (78%)

0.182

Atrial Fibrillation/Flutter

21 (20.2%)

6 (67%)

0.006

STS Predicted Risk of Mortality (STS PROM) (%)

3.8 ± 3.7

6.9 ± 4.2

0.024

Any AVR (Surgical or Transcatheter)

55 (53%)

4 (44.4%)

0.627

Echocardiographic

Interventricular Septal Thickness (cm)

1.3 ± 0.3

1.8 ± 0.5

< 0.001

Relative Wall Thickness (PWT/LVEDD)

0.5 ± 0.3

0.7 ± 0.3

0.147

Left Atrial Volume Index (ml/m2)

40 ± 15

51 ± 13

0.037

Septal s’ (cm/s)

4.8 ± 1.7

2.9 ± 1.0

0.008

Septal e’ (cm/s)

4.9 ± 2.0

3.5 ± 1.2

0.084

E/e’ ratio (Lateral)

18 ± 11

19 ± 4

0.942

E/e’ ratio (Septal)

25 ± 18

33 ± 10

0.281

LV Stroke Volume Index (ml/m2)

37 ± 12

25 ± 7

0.003

Indexed Aortic Valve Area (cm2/m2)

0.5 ± 0.2

0.4 ± 0.2

0.047

Severe AS (indexed AVA ≤ 0.6 cm2/m2)

80 (77%)

8 (89%)

0.43

AV Mean Gradient (mmHg)

31 ± 15

30 ± 14

0.924

Low-Flow, Low-Gradient Physiologya (%)

47 (45%)

7 (78%)

0.060

Pulmonary Artery Systolic Pressure (mmHg)

41 ± 13

45 ± 17

0.435

CMR

LV End-Diastolic Volume Index (ml/m2)

92 ± 33

82 ± 19

0.113

LV End-Systolic Volume Index (ml/m2)

48 ± 33

49 ± 22

0.131

LV Stroke Volume Index (ml/m2)

44 ± 13

33 ± 10

0.024

LV Ejection Fraction (%)

52 ± 18

43 ± 17

0.176

LV Mass Index (g/m2)

73 ± 21

105 ± 21

< 0.0001

LV Mass/Volume Ratio (LV Mass/LVEDV)

0.8 ± 0.2

1.3 ± 0.3

0.02

Native T1 mapping (msec)b

1035 ± 60

1125 ± 49

0.002

Extracellular Volume Fraction (ECV) (%)c

27.9 ± 4.1

41.2 ± 16.7

< 0.001

  1. Continuous variables are presented as mean ± standard deviation
  2. (a) Defined as LV stroke volume index <35 ml/m2 and mean AV gradient <40 mmHg. (b) Native T1 available in 74/104 AS patients and in 7/9 AS + CA patients). (c) ECV values available in 66/104 of AS patients and 5/9 patients with AS + CA)
  3. AS aortic stenosis, AVR aortic valve replacement, CA cardiac amyloidosis, CABG coronary artery bypass grafting, CMR cardiovascular magnetic resonance, ECV extracellular volume fraction, LV left ventricular, LVEDV left ventricular end-diastolic volume, NYHA New Yo0rk Heart Association, PCI percutaneous coronary intervention
Back to article page

Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

Contact us