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Table 3 Univariate Clinical and Imaging Predictors of All-Cause Mortality

From: Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis

 

Variable

X2

HR (95% CI)

P Value

Clinical

Age (per 1 year)

10.6

1.05 (1.02, 1.08)

0.001

Male Gender

7.8

2.89 (1.37, 6.10)

0.005

NYHA Class ≥ III

9.1

3.18 (1.50, 6.73)

0.003

Hypertension

0.35

1.26 (0.58, 2.74)

0.55

Diabetes

1.72

1.52 (0.81, 2.83)

0.19

Prior Coronary Revascularization

8.1

2.48 (1.33, 4.65)

0.004

Atrial Fibrillation/Flutter

4.56

2.07 (1.06, 4.03)

0.03

Any AVR (vs. Medical Therapy)

12.0

0.30 (0.15, 0.59)

0.001

STS PROM (per 1% increase)

21.5

1.15 (1.09, 1.23)

< 0.001

Echocardiographic

Interventricular Septal Thickness (per 1 cm)

4.1

3.14 (1.03, 9.56)

0.04

Left Atrial Volume Index (per 1 ml/m2)

20.7

1.04 (1.02, 1.06)

< 0.001

LV Stroke Volume Index (per 1 ml/m2)

10.8

0.95 (0.92, 0.98)

0.001

Septal s’ (per 1 cm/s)

2.65

0.77 (0.56, 1.06)

0.10

E/e’ ratio (lateral)

3.1

1.03 (0.99, 1.06)

0.08

E/e’ ratio (septal)

6.6

1.02 (1.006, 1.04)

0.01

AV Peak Velocity (per 1 m/s)

2.76

0.71 (0.48, 1.06)

0.097

AV Mean Gradient (per 1 mmHg)

2.2

0.98 (0.96, 1.00)

0.13

Aortic Valve Index (per 1 cm2/m2)

3.8

0.12 (0.01, 1.00)

0.05

Dimensionless Index

1.2

0.14 (0.005, 4.32)

0.26

Pulmonary Artery Systolic Pressure (per 1 mmHg)

10.0

1.03 (1.01, 1.06)

0.002

CMR

Presence of Cardiac Amyloidosis on CMR

8.1

4.10 (1.55, 10.84)

0.004

LV Ejection Fraction (per 1%)

17.6

0.96 (0.95, 0.98)

< 0.001

LV End-Diastolic Volume Index (per 1 ml/m2)

6.8

1.01 (1.003, 1.02)

0.009

LV End-Systolic Volume Index (per 1 ml/m2)

10.8

1.01 (1.006, 1.02)

0.001

LV Stroke Volume Index (per 1 ml/m2)

4.4

0.97 (0.94, 0.99)

0.037

LV Mass Index (per 1 g/m2)

10.2

1.02 (1.008, 1.04)

0.001

LV Mass/Volume Ratio

0.006

1.05 (0.30, 3.70)

0.937