From: Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis
Variable | X2 | HR (95% CI) | P Value | |
---|---|---|---|---|
Clinical | Age (per 1 year) | 10.6 | 1.05 (1.02, 1.08) | 0.001 |
Male Gender | 7.8 | 2.89 (1.37, 6.10) | 0.005 | |
NYHA Class ≥ III | 9.1 | 3.18 (1.50, 6.73) | 0.003 | |
Hypertension | 0.35 | 1.26 (0.58, 2.74) | 0.55 | |
Diabetes | 1.72 | 1.52 (0.81, 2.83) | 0.19 | |
Prior Coronary Revascularization | 8.1 | 2.48 (1.33, 4.65) | 0.004 | |
Atrial Fibrillation/Flutter | 4.56 | 2.07 (1.06, 4.03) | 0.03 | |
Any AVR (vs. Medical Therapy) | 12.0 | 0.30 (0.15, 0.59) | 0.001 | |
STS PROM (per 1% increase) | 21.5 | 1.15 (1.09, 1.23) | < 0.001 | |
Echocardiographic | Interventricular Septal Thickness (per 1 cm) | 4.1 | 3.14 (1.03, 9.56) | 0.04 |
Left Atrial Volume Index (per 1 ml/m2) | 20.7 | 1.04 (1.02, 1.06) | < 0.001 | |
LV Stroke Volume Index (per 1 ml/m2) | 10.8 | 0.95 (0.92, 0.98) | 0.001 | |
Septal s’ (per 1 cm/s) | 2.65 | 0.77 (0.56, 1.06) | 0.10 | |
E/e’ ratio (lateral) | 3.1 | 1.03 (0.99, 1.06) | 0.08 | |
E/e’ ratio (septal) | 6.6 | 1.02 (1.006, 1.04) | 0.01 | |
AV Peak Velocity (per 1 m/s) | 2.76 | 0.71 (0.48, 1.06) | 0.097 | |
AV Mean Gradient (per 1 mmHg) | 2.2 | 0.98 (0.96, 1.00) | 0.13 | |
Aortic Valve Index (per 1 cm2/m2) | 3.8 | 0.12 (0.01, 1.00) | 0.05 | |
Dimensionless Index | 1.2 | 0.14 (0.005, 4.32) | 0.26 | |
Pulmonary Artery Systolic Pressure (per 1 mmHg) | 10.0 | 1.03 (1.01, 1.06) | 0.002 | |
CMR | Presence of Cardiac Amyloidosis on CMR | 8.1 | 4.10 (1.55, 10.84) | 0.004 |
LV Ejection Fraction (per 1%) | 17.6 | 0.96 (0.95, 0.98) | < 0.001 | |
LV End-Diastolic Volume Index (per 1 ml/m2) | 6.8 | 1.01 (1.003, 1.02) | 0.009 | |
LV End-Systolic Volume Index (per 1 ml/m2) | 10.8 | 1.01 (1.006, 1.02) | 0.001 | |
LV Stroke Volume Index (per 1 ml/m2) | 4.4 | 0.97 (0.94, 0.99) | 0.037 | |
LV Mass Index (per 1 g/m2) | 10.2 | 1.02 (1.008, 1.04) | 0.001 | |
LV Mass/Volume Ratio | 0.006 | 1.05 (0.30, 3.70) | 0.937 |