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Table 1 Baseline characteristics of the AL amyloidosis patients and healthy controls

From: The prognostic value of T1 mapping and late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with light chain amyloidosis

Characteristics

Patients

n = 82

Healthy controls

n = 20

P

Clinical

 Male/female

52/30

10/10

0.27

 Age (years)

55.5 ± 8.5

53.2 ± 11.7

0.30

 NYHA (I/II/III/IV)

30/24/23/5

–

–

 cTnI (μg/L)

0.043 (0.015–0.146)

0.000 (0.000–0.040)

0.024

 NT-proBNP (pg/mL)

2056 (348–6096)

0 (0–23)

0.001

 dFLC (mg/L)

138.0 (46.0–391.5)

–

–

 Mayo Stage (I/II/III/IV)

22/18/29/13

–

–

 Creatinine (umol/L)

87.3 ± 21.6

74.9 ± 15.3

0.21

 HTN/CHD/DM/Af

16/6/3/2

–

–

 Therapy (BCD/TCD/ASCT)

5/4/2

–

–

Echocardiography

 E/A

1.3 ± 0.7

–

–

 E/E’

16.8 ± 8.3

–

–

Cardiac MR

 Indexed LVEDV (ml/m2)

58.3 ± 16.0

74.5 ± 17.1

0.001

 Indexed LVESV (ml/m2)

22.1 ± 12.4

21.5 ± 8.1

0.79

 LVEF (%)

63.3 ± 14.6

70.3 ± 8.7

0.043

 Left atrium area (cm2)

21.4 ± 5.0

20.6 ± 5.0

0.52

 Indexed left ventricle mass (g/m2)

93.5 ± 29.0

65.2 ± 15.3

0.001

 Septal thickness (mm)

15.4 ± 4.0

10.5 ± 2.0

0.001

 LGE (no/patchy/global)

26/18/38

–

–

 Native T1 (ms)

1438 ± 120

1283 ± 46

0.001

 ECV (%)

43.9 ± 10.9

27.0 ± 1.7

0.001

  1. All continuous variables are presented as mean ± SD, except for cTnI, NT-proBNP and dFLC, which are presented as medians (quartiles 1-quartiles 3). cTnI Cardiac Troponin I, NT-proBNP N-terminal pro-B-type natriuretic peptide, dFLC Serum immunoglobulin free light chain difference, NYHA New York Heart Association, HTN Hypertension, CHD Coronary artery heart disease, DM Diabetes mellitus, Af Atrial fibrillation, BCD Bortezomib, cyclophosphamide and dexamethasone, TCD Thalidomide, cyclophosphamide and dexamethasone, ASCT Autologous stem cell transplant, MR Magnetic resonance, LVEDV Left ventricle end-diastolic volume, LVESV Left ventricle end-systolic volume, LVEF Left ventricle ejection fraction, LGE Late gadolinium enhancement, ECV Extracellular volume