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Table 1 Baseline characteristics in sarcomere mutation carriers with and without left ventricular hypertrophy compared to healthy mutation-negative family member controls

From: Left Atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy

  G+/LVH+
HCM
(N = 34)
G+/LVH-
Preclinical
(N = 24)
G−/LVH-
Control
(N = 15)
P-value*
overall
P-value*
Preclinical
vs Control
P-value*
HCM
vs Preclinical
P-value*
HCM
vs Control
Age, years 33 ± 12 27 ± 10 24 ± 6 <0.001 0.1 <0.001 <0.001
Male, n (%) 25 (74%) 12 (50%) 7 (47%) 0.003 0.8 0.008 0.007
G+ mutation, n (%)
 MYH7 6 (18%) 11 (46%) 0     
 MYBPC3 21 (62%) 10 (42%) 0     
 TNNT2 5 (14%) 1 (4%) 0     
 TNNI3 1 (3%) 1 (4%) 0     
 MYL2 1 (3%) 0 (0%) 0     
 MYL3 0 (0%) 0 (0%) 0     
 ACTC 0 (0%) 1 (4%) 0     
BMI,kg/m2 28.0 ± 4.3 24.0 ± 3.8 27.0 ± 4.5 0.4 0.6 0.2 0.4
SBP, mmHg 120 ± 11 115 ± 13 122 ± 14 0.7 0.5 1.0 0.7
DBP, mmHg 70 ± 7 70 ± 8 71 ± 9 0.6 0.8 0.4 0.7
IVS, mm 16.0 ± 5.3 9.0 ± 1.2 8.9 ± 1.2 <0.001 0.5 <0.001 <0.001
PW, mm 10.0 ± 2.2 7.9 ± 1.2 7.8 ± 1.6 <0.001 0.3 <0.001 <0.001
Maximal LVWT, mm 16.0 ± 5.1 10.0 ± 2.1 9.7 ± 1.5 <0.001 0.7 <0.001 <0.001
LVEF, % 66 ± 9.4 63.0 ± 6.3 60.0 ± 4.4 0.003 0.8 0.008 <0.001
Max LVOT, m/s 1.3 ± 0.2 1.3 ± 0.2 1.6 ± 0.5 0.036 0.7 0.052 0.2
LV mass, g 189 ± 53 121 ± 29 136 ± 34 <0.001 0.1 <0.001 <0.001
LV massi, g/m2 93 ± 24 66 ± 15 72 ± 15 <0.001 0.2 <0.001 0.012
LVEDVi, ml/ m2 45 ± 14 47 ± 9.3 51 ± 14 0.4 0.5 0.6 0.4
Septal e’ (cm/s) 9.8 ± 2.9 12 ± 2.0 14 ± 2.0 <0.001 0.003 0.047 <0.001
Septal e’/a’ ratio 1.2 ± 0.4 1.7 ± 0.5 1.9 ± 0.6 0.001 0.026 0.3 <0.001
Lateral e’ (cm/s) 14 ± 4.2 16 ± 2.4 16 ± 3.0 0.4 0.6 0.5 0.6
Lateral e’/a’ ratio 1.7 ± 0.8 2.2 ± 1.0 2.5 ± 1.0 0.15 0.6 0.7 0.2
Global E’, cm/s 12 ± 3.4 15 ± 1.9 16 ± 2.3 <0.001 0.1 <0.001 <0.001
Log-NT-proBNP, pg/mL 286 ± 464 51 ± 43 30 ± 28 <0.001 0.5 <0.001 <0.001
LGE, n, % present 17 (50%) 0 (0%) 0 (0%)
  1. LVH was based on echocardiographic core laboratory measurements, defined as a maximal LV wall thickness (LVWT) ≥12 mm in adults or a z-score ≥ 3 in participants <18 years of age. LV left ventricular, SBP systolic blood pressure, DBP diastolic blood pressure, BSA body surface area, IVS interventricular septum thickness measured by echocardiography, PW posterior wall thickness measured by echocardiography, Max LVWT maximal left ventricular wall thickness, measured by MRI, defined as the largest measurement in each of four segments (anterior and posterior septal, lateral and inferior), LVEF left ventricular ejection fraction, Max LVOT maximal left ventricular outflow tract velocity, LVEDVi Left ventricular End Diastolic Volume indexed to BSA, E’ tissue Doppler early diastolic myocardial relaxation velocity, LGE late gadolinium enhancement. Values represent mean and SD unless otherwise indicated
  2. *Adjusted for age, gender, BSA and family relationships; P values ≤0.017 were considered to indicate statistical significance, applying Bonferroni correction for multiple comparisons across the three groups