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Table 3 Regression analysis of left atrial function and measures of cardiac structure, function and serum biomarkers in the HCMnet cohort (N = 73)

From: Left Atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy

  LAPEmF LAAEmF LATEmF LAVmin* LAVbac* LAVmax*
IVS −0.88 (.18) <0.001 −0.28 (.19) 0.1 −0.70 (.20) 0.001 0.57 (.28) 0.046 0.85 (.36) 0.023 0.72 (.43) 0.097
LVEF −0.088 (.18) 0.6 0.23 (.17) 0.2 −0.10 (.20) 0.6 −0.24 (.24) 0.3 −0.25 (.30) 0.4 −0.30 (.32) 0.4
LAVmin* −0.007 (0.001) <0.001 −0.005 (0.0007) <0.001 −0.008 (0.0008) <0.001
LAVbac* −0.005 (0.0007) <0.001 −0.002 (0.0007) 0.018 −0.005 (0.0008) <0.001
LAVmax* −0.002 (.0008) 0.004 −0.002 (.0009) 0.058 −0.003 (.0009) 0.003
LVEDV −0.004 (.040) 0.9 −0.034 (.043) 0.4 −0.023 (.039) 0.6 0.075 (.044) 0.092 0.11 (.059) 0.073 0.17 (.08) 0.027
LVESV 0.053 (.086) 0.5 −0.087 (.083) 0.3 −0.028 (.086) 0.7 0.14 (.10) 0.2 0.19 (.13) 0.1 0.32 (.16) 0.046
LV mass −0.099 (.022) <0.001 0.002 (.026) 1.0 −0.060 (.025) 0.022 0.083 (.024) 0.001 0.13 (.03) <0.001 0.13 (.04) 0.001
Extent LGE −0.43 (.20) 0.046 −0.55 (.24) 0.034 −0.74 (.22) 0.005 1.23 (.26) <0.001 1.35 (.33) <0.001 1.32 (.37) 0.002
Septal e’ (cm/s) 0.01 (.005) 0.067 −0.001 (.004) 0.8 0.005 (.004) 0.3 −0.77 (.40) 0.06 −1.20 (.55) 0.035 −1.09 (.73) 0.14
Septal e’/a’ ratio 0.04 (0.02) 0.13 −0.02 (.02) 0.3 0.008 (.01) 0.7 −0.31 (2.2) 0.9 −1.77 (2.9) 0.55 −1.8 (3.6) 0.6
Lateral e’ (cm/s) 0.004 (.005) 0.4 −0.001 (.003) 0.6 0.002 (.004) 0.6 −0.49 (.37) 0.19 −0.75 (.50) 0.14 −0.54 (.60) 0.4
Lateral e’/a’ ratio 0.004 (.02) 0.8 −0.02 (.008) 0.032 −0.008 (.01) 0.5 0.73 (1.2) 0.5 0.53 (1.9) 0.8 1.25 (2.4) 0.6
Global E’ 0.97 (.48) 0.050 0.021 (.41) 1.0 0.64 (.47) 0.2 −1.02 (.48) 0.037 −1.50 (.54) 0.021 −1.39 (.77) 0.079
Log-NT-proBNP −0.040 (.006) <0.001 −0.014 (.01) 0.16 −0.035 (.008) <0.001 3.55 (1.1) 0.002 4.53 (1.2) <0.001 3.99 (1.6) 0.013
Troponin I 2.1 (56) 1.0 −73 (48) 0.2 −78 (63) 0.2 146 (73) 0.069 130 (74) 0.1 86 (99) 0.4
MMP1 0.21 (.002) 0.5 0.10 (.21) 0.5 0.19 (.14) 0.2 −0.18 (0.20) 0.4 −0.27 (0.30) 0.4 −0.16 (0.44) 0.7
TIMP1 −0.002 (.005) 0.7 0.004 (.003) 0.2 0.004 (.004) 0.3 −0.005 (.005) 0.3 0.001 (.006) 0.3 0.008 (.007) 0.2
GAL3 0.24 (.46) 0.6 0.056 (.28) 0.049 0.53 (.36) 0.1 −0.50 (.30) 0.1 −0.60 (.43) 0.2 −0.83 (.55) 0.1
sST2 −0.21 (.10) 0.043 0.072 (.096) 0.5 −0.077 (.095) 0.4 −0.027 (.076) 0.7 −0.051 (.10) 0.6 −0.22 (.14) 0.1
  1. Reported as beta coefficient (SE) p-value in the regression model with left atrial function as the outcome (Y) and other echo, CMR and biomarker measures as predictor (X), adjusted for age, gender, BSA, and family relationship
  2. IVS interventricular septum thickness, LVEF left ventricular ejection fraction, LVEDV Left ventricular End Diastolic Volume, LVESV Left ventricular End Systolic Volume, LV left ventricular, LGE late gadolinium enhancement, E’ tissue Doppler early diastolic myocardial relaxation velocity, N-terminal pro-B-type natriuretic peptide (NT-proBNP); high sensitive troponin I (troponin I); matrix metalloproteinase-1 (MMP1); matrix metalloproteinase inhibitor-1 (TIMP1); galectin-3 (GAL3). *indexed to BSA