Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in heart failure with preserved ejection fraction – implications for clinical trials

Table 3 Characteristics of newly diagnosed hypertrophic cardiomyopathy patients

Patient	Age	HTN	Image modality	Image grade	Maximal wall thickness		Hypertrophy pattern		SAM	LVOTO	LGE hyperenhancement		Likelihood of HCM
Patient	Age	HTN	Image modality	Image grade	mm	region	ASH	Concentric	SAM	LVOTO	Mid-wall	Insertion point	Likelihood of HCM
A	71	+	TTE	2	15	Basal inferoseptum	–	+	–	–	n/a		Definite
A	71	+	CMR	2	19	Basal anteroseptum	+	–	–	–	+	+
^aB	85	–	TTE	3	12	Apical septum	–	+	–	–	n/a		Definite
^aB	85	–	CMR	3	10	Apical septum	–	–	–	–	–	–
C	79	+	TTE	1	15	Basal inferoseptum	–	+	+	–	n/a		Probable
C	79	+	CMR	2	15	Basal anteroseptum	+	–	–	–	–	+
D	37	–	TTE	1	17	Basal inferoseptum	u/a	u/a	u/a	u/a	n/a		Definite
D	37	–	CMR	3	22	Basal inferoseptum	–	+	–	–	+	+
E	68	+	TTE	2	16	Basal inferoseptum	–	+	–	–	n/a		Definite
E	68	+	CMR	2	21	Basal anteroseptum	+	–	–	–	+	–
F	87	+	TTE	2	12	Basal inferoseptum	–	+	+	+	n/a		Probable
F	87	+	CMR	3	15	Basal anteroseptum	+	–	+	+	+	+
G	62	+	TTE	2	13	Basal inferoseptum	–	+	+	–	n/a		Probable
G	62	+	CMR	2	15	Basal inferoseptum	+	–	+	–	–	–
H	70	+	TTE	1	14	Basal anteroseptum	–	+	–	–	n/a		Probable
H	70	+	CMR	2	15	Mid inferoseptum	+	–	–	–	+	–
I	74	–	TTE	1	14	Basal anteroseptum	–	+	–	–	n/a		Probable
I	74	–	CMR	3	17	Basal inferoseptum	–	+	–	–	–	–
J	72	+	TTE	1	16	Basal anteroseptum	–	+	–	–	n/a		Probable
J	72	+	CMR	3	18	Basal anteroseptum	+	–	–	–	+	–

Abbreviations: TTE = transthoracic echocardiography; CMR = cardiac magnetic resonance; HTN = hypertension, LGE = late gadolinium enhancement imaging; u/a = unable to assess; n/a = not applicable; − = absent; + = present
Image grade: 1 = poor; 2 = fair; 3 = good
Diagnostic considerations for hypertrophic cardiomyopathy (HCM): LV wall thickness ≥ 15 mm, asymmetrical septal hypertrophy (ASH – septal: free wall thickness ratio > 1.3), apical HCM if apical wall thickness > 15 mm or apical:basal wall thickness ratio ≥ 1.3, left ventricular outflow tract obstruction (LVOTO) and systolic anterior motion of the mitral valve (SAM)
^aNote: Patient B was diagnosed with apical HCM (spade-like configuration of the LV cavity and apical: basal wall thickness ratio ≥ 1.3)

ISSN: 1532-429X