Non-invasive differentiation of idiopathic inflammatory myopathy with cardiac involvement from acute viral myocarditis using cardiovascular magnetic resonance imaging T1 and T2 mapping

Table 2 CMR Imaging Parameters: ventricular geometry, strain and LGE

	Healthy controls (n = 20)	Acute viral myocarditis (n = 20)	IIM with inflammatory myocarditis (n = 20)	P-value / age adjusted p-value
LV
- EDV index, ml/m2	79 ± 16	85 ± 12	78 ± 15	0.059
- ESV index, ml/m2	32 ± 6	40 ± 8/	35 ± 13	0.038 / 0.329
- Mass index, ml/m2	54 ± 11	60 ± 10	55 ± 14	0.099
- EF, %	59 ± 4	53 ± 9/	56 ± 10	0.198
- GLS, %	−25 ± 3	−24 ± 5	−23 ± 6*	0.235
RV
- EDV index, ml/m2	98 ± 21	99 ± 21	82 ± 19/	0.004 / 0.036
- ESV index, ml/m2	48 ± 14	50 ± 11	40 ± 19*	0.010 / 0.091
- EF, %	51 ± 7	49 ± 4	53 ± 12	0.026 / 0.396
- GLS, %	−32 ± 8	−32 ± 7	−33 ± 9	0.659
LGE
LGE positive patients	0/20 (0%)	20/20 (100%)*	7/20 (35%)*	< 0.001
Subepicardial LGE positive segments	0/340 (0%)	106/340	9/340 (5%)*	< 0.001
Intramural LGE positive segments	0/340 (0%)	(31%)*	9/340 (3%)*	0.004
Subendocardial LGE positive segments	0/340 (0%)	0/340 (0%)	0/340 (0%)

Values are mean ± SD or n / total (%). */* p < .05 compared to controls without / with age adjustment. p-values/age adjusted p-values of the direct comparison between acute viral myocarditis and IIM myocarditis are shown in the last column, using Mann-Whitney U and a multivariate regression model or Fisher’s exact test, as appropriate. Age adjusted p-values were calculated in case of significant non-adjusted p-values
IIM idiopathic inflammatory myopathy, LV left ventricular, EDV end-diastolic volume, ESV end-systolic volume, EF ejection fraction, GLS global longitudinal strain

ISSN: 1532-429X