| |
Healthy controls (n = 20)
|
Acute viral myocarditis (n = 20)
|
IIM with inflammatory myocarditis (n = 20)
|
p-value / age adjusted p-value
|
|---|
|
Myocardium including LGE positive segments
|
|
T1 native, ms
|
965 ± 25
|
1044 ± 63*/*
|
1017 ± 43*/*
|
0.121
|
|
T1 contrast 15 min, ms
|
379 ± 54
|
320 ± 34*/*
|
326 ± 54*/*
|
0.925
|
|
ECV, %
|
22 ± 3
|
24 ± 7*/*
|
23 ± 3
|
0.134
|
|
T2, ms
|
48 ± 2
|
53 ± 4*/*
|
53 ± 3*/*
|
0.758
|
|
Myocardium excluding LGE positive segment
|
|
T1 native, ms
|
965 ± 25
|
1023 ± 52*/*
|
1011 ± 36*/*
|
0.445
|
|
T1 contrast 15 min, ms
|
379 ± 54
|
330 ± 38*/*
|
328 ± 51*/*
|
0.718
|
|
ECV, %
|
22 ± 3
|
25 ± 3*/*
|
23 ± 4
|
0.351
|
|
T2, ms
|
48 ± 2
|
51 ± 3*/*
|
52 ± 3*/*
|
0.174
|
|
Skeletal Muscles
|
|
T1 native, ms
|
842 ± 39
|
844 ± 62
|
963 ± 127*/*
|
0.001 / 0.002
|
|
T1 contrast 15 min, ms
|
510 ± 43
|
482 ± 39*/*
|
374 ± 55*/*
|
< 0.001 / < 0.001
|
|
ECV, %
|
10 ± 2
|
10 ± 3
|
19 ± 7*/*
|
< 0.001 / < 0.001
|
|
T2, ms
|
40 ± 2
|
38 ± 2*
|
45 ± 10
|
< 0.001 / 0.022
|
- Values are mean ± SD. */* p < .05 compared to controls without / with age adjustment. p-values/age adjusted p-values of the direct comparison between acute viral myocarditis and IIM myocarditis are shown in the last column, using Mann-Whitney U test and a multivariate regression model. Age adjusted p-values were only calculated in case of significant non-adjusted p-values
- IIM idiopathic inflammatory myopathy, ECV extracellular volume fraction, SD Standard deviation
