Fig. 4

Pixel-wise Stress and Rest Myocardial Blood Flow in Remote Myocardium, Dark Rim Artifacts, Intermediate-CAD, and Severe-CAD. In the subgroup analysis of NonCAD with dark rim artifacts, the subendocardium of the dark rim artifacts region was the only layer with lower stress MBF compared to the remote myocardium. In patients with both intermediate CAD (50–69% QCA stenosis) and severe CAD (QCA ≥ 70%), stress MBF in all layers of the myocardium was lower than the corresponding remote region. Rest MBF measurements did not differentiate true positive CAD region from remote myocardium